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Titolo:
Distribution of serotonin 5-HT2A receptors in afferents of the rat striatum
Autore:
Bubser, M; Backstrom, JR; Sanders-Bush, E; Roth, BL; Deutch, AY;
Indirizzi:
Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Psychiat, Nashville, TN 37212 USA Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Pharmacol, Nashville, TN 37212 USA Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Neurosci, Nashville, TN 37212 USA Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 297 - 304
SICI:
0887-4476(20010315)39:4<297:DOS5RI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL-INDUCED CATALEPSY; ATYPICAL ANTIPSYCHOTIC-DRUGS; PARVALBUMIN-IMMUNOREACTIVE NEURONS; DECARBOXYLASE MESSENGER-RNA; QUINOLINIC ACID LESIONS; EARLY GENE-EXPRESSION; LOW-DOSE CLOZAPINE; LIVING HUMAN-BRAIN; GLOBUS-PALLIDUS; PARKINSONS-DISEASE;
Keywords:
antipsychotic drug; cortex; dopamine; extrapyramidal side effects; globus pallidus; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Deutch, AY Vanderbilt Univ, Hosp Psychiat, Suite 313,1601 23rd Ave S, Nashville, TN 37212 USA Vanderbilt Univ Suite 313,1601 23rd Ave S Nashville TN USA 37212
Citazione:
M. Bubser et al., "Distribution of serotonin 5-HT2A receptors in afferents of the rat striatum", SYNAPSE, 39(4), 2001, pp. 297-304

Abstract

Treatment with conventional antipsychotic drugs (APDs) is accompanied by extrapyramidal side effects (EPS), which are thought to be due to striatal dopamine D-2 receptor blockade. In contrast, treatment with atypical APDs ismarked by a low incidence or absence of EPS. The reduced motor side effectliability of atypical APDs has been attributed to a high serotonin 5-HT2A receptor affinity coupled with a relatively low D-2 affinity. Despite the high density of 5-HT2A binding sites in the striatum, there are few detectable 5-HT2A mRNA-expressing neurons in the striatum. This suggests that most striatal 5-HT2A receptors are heteroceptors located on afferent axons. A combined retrograde tracer-immunohistochemistry method was used to determine the sites of origin of striatal 5-HT2A-like immunoreactive axons. 5-HT2A-like immunoreactive neurons in both the cortex and globus pallidus were retrogradely labeled from the striatum; very few nigrostriatal or thalamostriatal neurons expressed 5-HT2A-like immunoreactivity. Within the striatum, parvalbumin-containing interneurons displayed 5-HT2A immunolabeling; these neurons are the targets of cortical and pallidal projections. Our data indicatethat cortico- and pallido-striatal neurons are the major source of 5-HT2A receptor binding in the striatum, and suggest that cortico- and pallido-striatal neurons are strategically positioned to reduce the motor side effectsthat accompany striatal D-2 receptor blockade or are seen in parkinsonism. Synapse 39: 297-304, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 22/01/20 alle ore 09:28:24