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Titolo:
Assessment of muscarinic receptor concentrations in affinity and Alzheimerdisease with [C-11]NMPB and PET
Autore:
Zubieta, JK; Koeppe, AR; Frey, KA; Kilbourn, MR; Mangner, TJ; Foster, NL; Kuhl, DE;
Indirizzi:
Univ Michigan, Dept Psychiat, Ann Arbor, MI 48104 USA Univ Michigan Ann Arbor MI USA 48104 pt Psychiat, Ann Arbor, MI 48104 USA Univ Michigan, Dept Internal Med, Div Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Nucl Med, Ann Arbor, MI 48109 USA Univ Michigan, Dept Neurol, Ann Arbor, MI USA Univ Michigan Ann Arbor MI USA Michigan, Dept Neurol, Ann Arbor, MI USA
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 39, anno: 2001,
pagine: 275 - 287
SICI:
0887-4476(20010315)39:4<275:AOMRCI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL BLOOD-FLOW; CHOLINE-ACETYLTRANSFERASE ACTIVITY; HUMAN-BRAIN; ACETYLCHOLINE-RECEPTORS; RAT-BRAIN; BINDING-SITES; COMPUTED-TOMOGRAPHY; PARKINSONS-DISEASE; FRONTAL-CORTEX;
Keywords:
acetylcholine; neurodegeneration; receptor quantification; dementias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Zubieta, JK Univ Michigan, Dept Psychiat, Neurosci Bldg,1103 E Huron St, Ann Arbor, MI48104 USA Univ Michigan Neurosci Bldg,1103 E Huron St Ann ArborMI USA 48104
Citazione:
J.K. Zubieta et al., "Assessment of muscarinic receptor concentrations in affinity and Alzheimerdisease with [C-11]NMPB and PET", SYNAPSE, 39(4), 2001, pp. 275-287

Abstract

Cerebral cholinergic deficits have been described in Alzheimer disease (AD) and as a result of normal aging. At the present time, there are very limited options for the quantification of cholinergic receptors with in vivo imaging techniques such as PET. In the present study, we examined the feasibility of utilizing [C-11]N-methyl-4-piperidyl benzilate (NMPB), a nonselective muscarinic receptor ligand, in the study of aging and neurodegenerative processes associated with cholinergic dysfunction. Based on prior data describing the accuracy of various kinetic methods, we examined the concentration of muscarinic receptors with [C-11]NMPB and PET using two- and three-compartment; kinetic models. Eighteen healthy subjects and six patients diagnosed with probable AD were studied. Pixel-by-pixel two-compartment model fits showed acceptable precision in the study of normal aging, with comparableresults to those obtained with a more complex and less precise three-compartment model. Normal aging was associated with a reduction in muscarinic receptor binding in neocortical regions and thalamus. In AD patients, the three-compartment model appeared capable of dissociating changes in tracer transport from changes in receptor binding, but suffered from statistical uncertainty, requiring normalization to a reference region, and therefore limiting its potential use in the study of neurodegenerative processes. After normalization, no regional changes in muscarinic receptor concentrations wereobserved in AD. Synapse 39:275-287, 2001, (C) 2001 Wiley-Liss, Inc.

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Documento generato il 04/06/20 alle ore 01:50:04