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Titolo:
Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver
Autore:
Jeon, BR; Yeom, DH; Lee, SM;
Indirizzi:
Sung Kyun Kwan Univ, Coll Pharm, Changan Gu, Suwon 440746, South Korea Sung Kyun Kwan Univ Suwon South Korea 440746 , Suwon 440746, South Korea
Titolo Testata:
SHOCK
fascicolo: 2, volume: 15, anno: 2001,
pagine: 112 - 117
SICI:
1073-2322(200102)15:2<112:PEOAOH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
XANTHINE-OXIDASE; INJURY; LEVEL; DYSFUNCTION; INDICATOR; ADENOSINE; STRESS; OXYGEN;
Keywords:
allopurinol; xanthine oxidase; glutamate dehydrogenase; total adenine nucleotide; total purine bases; hepatic ischemia/reperfusion; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SM Sung Kyun Kwan Univ, Coll Pharm, Changan Gu, 300 Chonchon Dong, Suwon 440746, South Korea Sung Kyun Kwan Univ 300 Chonchon Dong Suwon South Korea 440746 ea
Citazione:
B.R. Jeon et al., "Protective effect of allopurinol on hepatic energy metabolism in ischemic and reperfused rat liver", SHOCK, 15(2), 2001, pp. 112-117

Abstract

Reactive oxygen species generated by xanthine oxidase during reperfusion of ischemic liver might in part be responsible for ischemic organ injury. Innormothermic ischemia/reperfusion rat model, we investigated whether allopurinol pretreatment improved ischemia-induced mitochondrial dysfunction. Rats were subjected to 60 min of hepatic ischemia and to 1 h and 5 h of reperfusion thereafter. At 18 h and 1 h before ischemia, the animals received 0.25 mL of either saline or allopurinol (50 mg/kg) i.p. In saline-treated ischemic rats, serum aspartate aminotransferase levels increased significantlyat 5 h (4685 +/- 310 IU/L) and were significantly reduced with allopurinolpretreatment. Similarly, mitochondrial lipid peroxidation was elevated in the saline-treated ischemic group, but this elevation was prevented by allopurinol. In contrast, mitochondrial glutamate dehydrogenase activity and ketone body ratio decreased in the saline-treated group, but this decrease was also inhibited by allopurinol, Hepatic ATP levels in the saline-treated rats were 42% lower 5 h after reperfusion. However, treatment with allopurinol resulted in significantly higher ATP levels. Allopurinol treatment preserved the concentration of AMP in ischemic liver but inhibited the accumulation of xanthine in reperfused liver. Our findings suggest allopurinol protects against mitochondrial injury, which prevents a mitochondrial oxidant stress and lipid peroxidation and preserves the hepatic energy metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:19:16