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Titolo:
Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy
Autore:
Soller, BR; Cingo, N; Puyana, JC; Khan, T; Hsi, C; Kim, H; Favreau, J; Heard, SO;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Surg, Worcester, MA 01605 USA Univ Massachusetts Worcester MA USA 01605 t Surg, Worcester, MA 01605 USA Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Surg, Boston, MA 02115 USA Univ Massachusetts, Sch Med, Dept Anesthesiol, Worcester, MA USA Univ Massachusetts Worcester MA USA Dept Anesthesiol, Worcester, MA USA
Titolo Testata:
SHOCK
fascicolo: 2, volume: 15, anno: 2001,
pagine: 106 - 111
SICI:
1073-2322(200102)15:2<106:SMOHTP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL LEAST-SQUARES; MAGNETIC-RESONANCE SPECTROSCOPY; CRITICALLY ILL PATIENTS; HEMORRHAGIC-SHOCK; END-POINTS; REFLECTANCE SPECTROSCOPY; RESUSCITATION; TRAUMA; DELIVERY; BLOOD;
Keywords:
hemorrhagic shock; swine; liver; anaerobic metabolism; physiologic monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Soller, BR Univ Massachusetts, Sch Med, Dept Surg, 55 Lake Ave N, Worcester, MA 01605USA Univ Massachusetts 55 Lake Ave N Worcester MA USA 01605 1605USA
Citazione:
B.R. Soller et al., "Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy", SHOCK, 15(2), 2001, pp. 106-111

Abstract

The purpose of this study was to investigate the feasibility of using nearinfrared (NIR) spectroscopy of the liver to simultaneously assess oxygen content in combination with tissue pH, an indicator of anaerobic metabolism. Six anesthetized swine were subjected to 45 min of hemorrhagic shock followed by resuscitation with blood and crystalloid. Calibration models betweenNIR spectra and reference measurements of tissue pH, hepatic venous oxygensaturation (SvO2), and blood hemoglobin concentration (Hb) were developed using partial least-squares regression. Model accuracy was assessed using cross validation. The average correlation (R-2) between NIR and reference measurements was 0.87, 0.68, and 0.93, respectively for pH, Hb, and SvO2. Estimated accuracy, the root mean squared deviation between spectral, and reference measurements was 0.03 pH units, 0.3 g/dL, and 6%. NIR determination of hepatic oxygen content and tissue pH during shock and resuscitation demonstrated that there can be a variance between hepatic venous oxygenation andregional tissue acidosis. NIR spectroscopy provides a technique to explorethe implications of post-shock depression of tissue pH and evaluate new methods of resuscitation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 07:11:22