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Titolo:
Sustained virological response in chronic hepatitis C patients after a 6-and a 36-month interferon-alpha 2b treatment schedule - A multicenter, randomized, controlled study
Autore:
Damen, M; Weegink, CJ; Mauser-Bunschoten, EP; Cuypers, HTM; Hermus, MC; Sillekens, P; Haan, E; van den Berg, HM; Bresters, D; Lelie, PN; Chamuleau, RAFM; Reesink, HW;
Indirizzi:
Acad Med Ctr, Dept Liver Dis, NL-1100 DD Amsterdam, Netherlands Acad Med Ctr Amsterdam Netherlands NL-1100 DD DD Amsterdam, Netherlands Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Viral Diagnost Dept,Amsterdam, Netherlands Netherlands Red Cross Amsterdam Netherlands Dept,Amsterdam, Netherlands Blood Bank N Holland, Amsterdam, Netherlands Blood Bank N Holland Amsterdam Netherlands land, Amsterdam, Netherlands Acad Hosp Utrecht, Van Creveldklin, Utrecht, Netherlands Acad Hosp Utrecht Utrecht Netherlands Creveldklin, Utrecht, Netherlands Organon Teknika, Boxtel, Netherlands Organon Teknika Boxtel NetherlandsOrganon Teknika, Boxtel, Netherlands Wilhelmina Childrens Hosp, Utrecht, Netherlands Wilhelmina Childrens HospUtrecht Netherlands osp, Utrecht, Netherlands
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 1, volume: 36, anno: 2001,
pagine: 97 - 104
SICI:
0036-5521(200101)36:1<97:SVRICH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; VIRUS-RNA LEVELS; LIVER-DISEASE; ANTI-HCV; THERAPY; TRIAL; RETREATMENT; INFECTION; ALFA-2B; ALPHA;
Keywords:
hepatitis C virus; hepatitis C virus-RNA; hepatitis C virus-viral load; hepatitis C; interferon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Reesink, HW Acad Med Ctr, Dept Gastroenterol & Hepatol, POB 22660, NL-1100DD Amsterdam, Netherlands Acad Med Ctr POB 22660 Amsterdam Netherlands NL-1100 DD lands
Citazione:
M. Damen et al., "Sustained virological response in chronic hepatitis C patients after a 6-and a 36-month interferon-alpha 2b treatment schedule - A multicenter, randomized, controlled study", SC J GASTR, 36(1), 2001, pp. 97-104

Abstract

Background: In patients with chronic hepatitis C (HCV) Interferon-alpha (IFN) treatment for 12-18 months is more effective than 6 months in inducing a sustained virological response. Methods: In a multicenter, randomized, controlled trial, 88 patients with chronic HCV were enrolled (47 treated withIFN-alpha 2b and 41 constituted an untreated control group). Treatment consisted of 5 million units (MU) IFN thrice a week (tiw) for 8 weeks and subsequently 2.5 MU IFN tiw for 16 weeks ('standard treatment'). After week 24 ('long-term treatment'), in virological non-responders treatment was continued using 5 MU IFN tiw for up to week 156, whereas in virological responders IFN was discontinued. In case of a virological relapse, treatment with 5 MU IFN tiw was restarted and continued up to week 156. Results: Sustained virological response rate was 6/47 (13%) after standard treatment and increased to 19/47 (40%) after long-term treatment (McNemar paired test; P = 0.002). Of the 18 patients with a breakthrough or relapse during or after standard treatment, 14 (78%) became sustained virological responders upon long-term treatment. Of the 4 patients who did not have a sustained virological response after long-term treatment, 3 did not receive complete treatment dueto side effects and/or non-compliance. In patients who failed to respond to standard treatment, no virological response was observed during long-termtreatment. In the control group, no spontaneous clearance of HCV was observed. Conclusions: Long-term IFN (re)treatment enhanced the virological sustained response rate significantly and was particularly effective in patients with a breakthrough or relapse following standard treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:18:16