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Titolo:
Post-operative complications after radiochemotherapy or chemotherapy for lung cancer
Autore:
Doddoli, C; Thomas, P; Reynaud-Gaubert, M; Giudicelli, R; Papazian, L; Fuentes, P;
Indirizzi:
Hop St Marguerite, Serv Chirurg Thorac, Marseille, France Hop St Marguerite Marseille France rv Chirurg Thorac, Marseille, France
Titolo Testata:
REVUE DES MALADIES RESPIRATOIRES
fascicolo: 6, volume: 17, anno: 2000,
pagine: 1081 - 1087
SICI:
0761-8425(200012)17:6<1081:PCAROC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
FRE
Soggetto:
STAGE-IIIA; PREOPERATIVE CHEMOTHERAPY; NEOADJUVANT THERAPY; RANDOMIZED TRIAL; PHASE-II; MULTIMODALITY THERAPY; INDUCTION TREATMENT; SURGICAL-TREATMENT; INTERIM ANALYSIS; SURGERY;
Keywords:
cancer; surgery; radiotherapy; chemotherapy; neoadjuvant; complications;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Doddoli, C Hop St Marguerite, Serv Chirurg Thorac, Marseille, France Hop St Marguerite Marseille France Thorac, Marseille, France
Citazione:
C. Doddoli et al., "Post-operative complications after radiochemotherapy or chemotherapy for lung cancer", REV MAL RES, 17(6), 2000, pp. 1081-1087

Abstract

Objective. The purpose of this study was to evaluate the risk of lung cancer surgery, following induction chemo and/or radiotherapy. Methods. This retrospective study included 69 patients treated from January 1990 to January 1998 for a primary lung cancer in whom surgery had been performed after induction treatment. Surgery had not been considered initially for the following reasons: N2 disease (IIIA: n = 25), temporary functional impairment (2 stages IB and 2 stages IIIA [N2]: n = 4): doubtful resectability (stage IIIB [T4]; n = 40). The medical regimen resulted in combined radio-chemotherapy in 43 patients who received 2 to 4 cycles of chemotherapy (average = 2.9 +/- 0.8 cycles) and 43 +/- 8 Gy (20 to 60 Gy), or chemotherapy alone in 26 patients (3 +/- 0.7 cycles). Results. Exploratory thoracotomy was performed in 4 patients (6%). The in-hospital mortality was 9% (n = 6) from respiratory origin in all cases. There were 4 reoperations (6%): 3 for bronchial fistula and 1 for bleeding. Thirty five patients (51%) required blood transfusion (4.5 +/- 3.8 cell packs). The incidence of early and delayed bronchial fistula after pneumonectomywas 15%. Thirteen patients had a postoperative pneumonia (19%). Conclusion. Surgery for lung cancer after induction chemo and/or radiotherapy is associated with an increased risk. While the mortality seems "acceptable", the morbidity rate however is high.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:39:29