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Titolo:
Thirty-plus functional families from a single motif
Autore:
Yu, LH; Gaitatzes, C; Neer, E; Smith, TE;
Indirizzi:
Boston Univ, Coll Engn, Biomol Engn Res Ctr, Boston, MA 02215 USA Boston Univ Boston MA USA 02215 Biomol Engn Res Ctr, Boston, MA 02215 USA Boston Univ, Sch Med, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 oston Univ, Sch Med, Boston, MA 02118 USA
Titolo Testata:
PROTEIN SCIENCE
fascicolo: 12, volume: 9, anno: 2000,
pagine: 2470 - 2476
SICI:
0961-8368(200012)9:12<2470:TFFFAS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIDDEN MARKOV-MODELS; WD-REPEAT PROTEIN; REGULATOR;
Keywords:
beta propeller; discrete state models; Hidden Markov models; WD-repeats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, TE BMERC, 36 Cummington St, Boston, MA 02215 USA BMERC 36 Cummington St Boston MA USA 02215 Boston, MA 02215 USA
Citazione:
L.H. Yu et al., "Thirty-plus functional families from a single motif", PROTEIN SCI, 9(12), 2000, pp. 2470-2476

Abstract

It is now possible to identify over 30 functional subfamilies among the WD-repeat-containing proteins found in the completed genomes. The majority ofthese subfamilies have at least one member for which experimental data allow assignment to a cellular pathway or process. Half of the 63 WD-repeat-containing proteins in Saccharomyces cerevisiae. half of the 70 in Caenorhabditis elegans. and a third of the 100 plus predicted in Drosophila can be assigned to 23 of these functional subfamilies. Perhaps indicative of the future, 33 WD-repeat-containing proteins from the partial genome of Arabidopsis thaliana can now be assigned to 18 of these subfamilies. These assignments have been made possible by combining traditional sequence similarity withan implied common beta propeller structural context to obtain measures of protein-protein surface similarity. The beta propeller structural context is represented in the form of a Hidden Markov Model. The procedure is completely automated.

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Documento generato il 24/09/20 alle ore 05:23:58