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Titolo:
Pharmacology and behavioral pharmacology of the mesocortical dopamine system
Autore:
Tzschentke, TM;
Indirizzi:
Grunenthal GmbH, Res & Dev, Dept Pharmacol, D-52088 Aachen, Germany Grunenthal GmbH Aachen Germany D-52088 harmacol, D-52088 Aachen, Germany
Titolo Testata:
PROGRESS IN NEUROBIOLOGY
fascicolo: 3, volume: 63, anno: 2001,
pagine: 241 - 320
SICI:
0301-0082(200102)63:3<241:PABPOT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; VENTRAL TEGMENTAL AREA; METHYL-D-ASPARTATE; FREELY-MOVING RATS; RECEPTOR MESSENGER-RNA; IBOTENIC ACID LESIONS; EXCITATORY AMINO-ACIDS; CONDITIONED PLACE PREFERENCE; BRAIN-STIMULATION REWARD; GAMMA-AMINOBUTYRIC-ACID;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
1276
Recensione:
Indirizzi per estratti:
Indirizzo: Tzschentke, TM Grunenthal GmbH, Res & Dev, Dept Pharmacol, Postfach 500444, D-52088 Aachen, Germany Grunenthal GmbH Postfach 500444 Aachen Germany D-52088 any
Citazione:
T.M. Tzschentke, "Pharmacology and behavioral pharmacology of the mesocortical dopamine system", PROG NEUROB, 63(3), 2001, pp. 241-320

Abstract

The prefrontal cortex (PFC) has long been known to be involved in the mediation of complex behavioral responses. Considerable research efforts are directed towards refining the knowledge about the function of this brain areaand the role it plays in cognitive performance and behavioral output. In the first part, this review provides, from a pharmacological perspective, anoverview of anatomical, electrophysiological and neurochemical aspects of the function of the PFC, with an emphasis on the mesocortical dopamine system. Anatomy of the mesocortical system, basic physiological and pharmacological properties of neurotransmission within the PFC. and interactions between dopamine and glutamate as well as other transmitters within the mesocorticolimbic circuit are included. The coverage of these data is largely restricted to what is relevant for the second part of the review which focuses on behavioral studies that have examined the role of the PFC in a variety ofphenomena, behaviors and paradigms. These include reward and addiction, locomotor activity and sensitization, learning, cognition, and schizophrenia. Although the focus of this: review is on the mesocortical dopamine system,given the intricate interactions of dopamine with other transmitter systems: within the PFC and the importance of the PFC as a sourer of glutamate insubcortical areas, these aspects are also covered in some detail where appropriate. Naturally, a topic as complex as this cannot be covered comprehensively in its entirety. Therefore this review is largely limited to data derived from studies using rats, and it is also specifically restricted to data concerning the medial PFC (mPFC). Since in several fields of research the findings concerning the function or role of the mPFC are relatively inconsistent, the question is addressed whether these inconsistencies might, at least in part, be related to the anatomical and functional heterogeneity ofthis brain area. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:58:32