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Titolo:
Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects
Autore:
Carlini, EJ; Raftogianis, RB; Wood, TC; Jin, F; Zheng, W; Rebbeck, TR; Weinshilboum, RM;
Indirizzi:
Mayo Clin & Mayo Fdn, Mayo Med Sch, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 peut, Rochester, MN 55905 USA Fox Chase Canc Ctr, Dept Pharmacol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Shanghai Canc Inst, Shanghai, Peoples R China Shanghai Canc Inst Shanghai Peoples R China , Shanghai, Peoples R China Univ S Carolina, Dept Epidemiol, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 t Epidemiol, Columbia, SC 29208 USA Univ Penn, Sch Med, Dept Biostat & Epidemiol, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Biostat, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Canc, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Ctr Canc, Philadelphia, PA 19104 USA
Titolo Testata:
PHARMACOGENETICS
fascicolo: 1, volume: 11, anno: 2001,
pagine: 57 - 68
SICI:
0960-314X(200102)11:1<57:SPSASA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERMOLABILE PHENOL SULFOTRANSFERASE; HUMAN ARYL SULFOTRANSFERASE; HUMAN-LIVER; CDNA CLONING; STRUCTURAL CHARACTERIZATION; BIOCHEMICAL-PROPERTIES; PARTIAL-PURIFICATION; MOLECULAR-CLONING; ASSAY CONDITIONS; PST ACTIVITY;
Keywords:
sulfotransferase; SULT; SULT1A1; SULT1A2; sulfate conjugation; sulfation; genetic polymorphism; pharmacogenetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Weinshilboum, RM Mayo Clin & Mayo Fdn, Mayo Med Sch, Dept Mol Pharmacol & Expt Therapeut, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn200 1st St SW Rochester MN USA 55905
Citazione:
E.J. Carlini et al., "Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects", PHARMACOGEN, 11(1), 2001, pp. 57-68

Abstract

Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of drugs,other xenobiotics, neurotransmitters and hormones. The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in levels of enzyme activity as well as variations in biochemical and physical properties. We set out to compare the frequencies of common SULT1A1 and SULT1A2 alleles in Caucasian, Chinese and African-American subjects. Allele frequencies for SULT1A1*1, *2 and *3 in 242 Caucasiansubjects were 0.656, 0.332 and 0.012, respectively. Frequencies of those same alleles were significantly different in 290 Chinese subjects: 0.914, 0.080 and 0.006, respectively, as were frequencies in 70 African-American subjects: 0.477, 0.294 and 0.229, respectively. Ethnic variation in allele frequencies was also observed for SULT1A2, with frequencies in Caucasian subjects for SULT1A2*1, *2 and *3 of 0.507, 0.389 and 0.104; frequencies in Chinese of 0.924 and 0.076 with no *3 alleles observed; and, finally, in African-Americans frequencies of 0.637, 0.249 and 0.114, respectively. We also found that SULT1A1*2 and SULT1A2*2, the most common variant alleles for thesetwo genes, were in positive linkage disequilibrium in all three populations studied, with D' values of 0.776 in Caucasian (P < 0.001), 0.915 in Chinese (P < 0.001) and 0.864 in African-American subjects (P < 0.001). These observations represent a step towards determining the possible functional implications for individual variations in sulfate conjugation of common genetic polymorphisms for SULT1A1 and SULT1A2. Pharmacogenetics 11:57-68 (C) 2001Lippincott Williams & Wilkins.

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Documento generato il 04/04/20 alle ore 15:00:48