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Titolo:
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population
Autore:
Loriot, MA; Rebuissou, S; Oscarson, M; Cenee, S; Miyamoto, M; Ariyoshi, N; Kamataki, T; Hemon, D; Beaune, P; Stucker, I;
Indirizzi:
Univ Paris 05, INSERM, U490, F-75006 Paris, France Univ Paris 05 Paris France F-75006 , INSERM, U490, F-75006 Paris, France Karolinska Inst, Inst Environm Med, Div Mol Toxicol, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 icol, S-10401 Stockholm, Sweden INSERM, U170, Villejuif, France INSERM Villejuif FranceINSERM, U170, Villejuif, France Hokkaido Univ, Grad Sch Pharmaceut Sci, Div Pharmacobiodynam, Lab Drug Metab, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ab, Sapporo, Hokkaido 060, Japan
Titolo Testata:
PHARMACOGENETICS
fascicolo: 1, volume: 11, anno: 2001,
pagine: 39 - 44
SICI:
0960-314X(200102)11:1<39:GPOCP2>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
COUMARIN 7-HYDROXYLATION; NICOTINE METABOLISM; CYP2A6; DELETION; IDENTIFICATION; FREQUENCY; SMOKING; RISK;
Keywords:
cytochrome P450 2A6; genetic polymorphism; lung cancer; tobacco consumption;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Beaune, P Univ Paris 05, INSERM, U490, 45 Rue St Peres, F-75006 Paris, France Univ Paris 05 45 Rue St Peres Paris France F-75006 aris, France
Citazione:
M.A. Loriot et al., "Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population", PHARMACOGEN, 11(1), 2001, pp. 39-44

Abstract

Cytochrome P450 2A6 (CYP2A6) is involved in the C-oxidation of nicotine and in the metabolic activation of tobacco nitrosamines. Recent data have suggested that CYP2A6 genetic polymorphisms might play a role in tobacco dependence and consumption as well as in lung cancer risk, However, the previously published studies were based on a genotyping method that overestimated the frequencies of deficient alleles, leading to misclassification for the CYP2A6 genotype, In this study, we genotyped DNA from 244 lung cancer patients and from 250 control subjects for CYP2A6 (wild-type allele CYP2A6*1, andtwo deficient alleles: CYP2A6*2, and CYP2A6*4, the latter corresponding toa deletion of the gene) using a more specific procedure. In this Caucasianpopulation, we found neither a relation between genetically impaired nicotine metabolism and cigarette consumption, nor any modification of lung cancer risk related to the presence of defective CYP2A6 alleles (odds ratio = 1.1, 95% confidence interval = 0.7-1.9). Pharmacogenetics 11:39-44 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:38:47