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Titolo:
Longitudinal study of peritoneal membrane function in continuous ambulatory peritoneal dialysis: Relationship with peritonitis and fibrosing factors
Autore:
Wong, TYH; Szeto, CC; Lai, KB; Lam, CWK; Lai, KN; Li, PKT;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Clin Pathol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
PERITONEAL DIALYSIS INTERNATIONAL
fascicolo: 6, volume: 20, anno: 2000,
pagine: 679 - 685
SICI:
0896-8608(200011/12)20:6<679:LSOPMF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EQUILIBRATION TEST; GROWTH-FACTORS; CAPD PATIENTS; LONG-TERM; TRANSPORT; HYALURONAN; KINETICS; CELLS;
Keywords:
peritonitis; TGF beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Szeto, CC Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut,Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China China
Citazione:
T.Y.H. Wong et al., "Longitudinal study of peritoneal membrane function in continuous ambulatory peritoneal dialysis: Relationship with peritonitis and fibrosing factors", PERIT DIA I, 20(6), 2000, pp. 679-685

Abstract

Background: The peritoneal equilibration test (PET) is a useful assessmentof peritoneal function in continuous ambulatory peritoneal dialysis (CAPD)patients. However, the natural course of longitudinal change in peritonealtransport is not well defined. Patients: We studied 105 unselected CAPD patients, Average age at enrollment was 50.7 +/- 11.3 years. Methods: A PET was performed at enrollment. Peritoneal transport was expressed as dialysate-to-plasma creatinine ratio at 4 hours (D/P). Fibrosing factors and mesothelial cell markers, including TGF beta, epidermal growth factor (EGF), platelet-derived growth factor (PDGF), hyaluronan, and cancer antigen 125 (CA125), were measured in overnight peritoneal dialysate effluent (PDE). Patients were followed for two years. Peritonitis episodes were recorded. Severe peritonitis was defined as an episode that required catheterremoval or antibiotic therapy for more than 3 weeks. After two years, 75 patients were still alive and on CAPD. Results: The PET was repeated in 64 patients, of whom 35 were male and 9 had diabetes. The change in D/P over two years was represented as DeltaD/P. No significant change in peritoneal transport was seen after two years (D/P: 0.56 +/- 0.12 vs 0.55 +/- 0.13). A centripetal pattern of change in DIP was observed, The DeltaD/P had normal distribution and was inversely correlated with D/P at baseline (r = -0,427, p < 0.005). Both results suggest a regression-to-mean phenomenon. The <Delta>D/P had no significant correlation with the total number of peritonitis episodes (Spearman r = 0.052, p = 0.74), but after severe peritonitis, affected patients had higher DeltaD/P thanpatients who experienced no severe infection (0.040 +/- 0.136 vs -0.032 +/- 0.120, p < 0.05). For patients with no episodes of severe peritonitis (n = 47), <Delta>D/P was weakly correlated with baseline TGF beta level (r = -0.506, p < 0.01). No correlation was seen between the levels of other fibrosing factors and change in peritoneal transport. Conclusions: Our findings suggest that the centripetal change of peritoneal transport probably reflects a regression-to-mean phenomenon. Peritoneal transport increases after severe peritonitis. The role of TGF<beta> levels in PDE with regard to longitudinal change in peritoneal transport requires further study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:18:30