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Titolo:
Brain proton magnetic resonance spectroscopy and imaging in children exposed to cocaine in utero
Autore:
Smith, LM; Chang, L; Yonekura, ML; Gilbride, K; Kuo, J; Poland, RE; Walot, I; Ernst, T;
Indirizzi:
Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Martin Res Ctr, Dept Pediat, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 diat, Torrance, CA 90502 USA Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Dept Neurol, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 urol, Torrance, CA 90502 USA Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Dept Radiol, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 diol, Torrance, CA 90502 USA Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Opt Recovery Ctr, Torrance, CA 90502 USA Univ Calif Los Angeles Torrance CA USA 90502 Ctr, Torrance, CA 90502 USA Univ Calif Los Angeles, Sch Med, Dept Psychiat, Cedars Sinai Med Ctr, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
PEDIATRICS
fascicolo: 2, volume: 107, anno: 2001,
pagine: 227 - 231
SICI:
0031-4005(200102)107:2<227:BPMRSA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIRTH-WEIGHT INFANTS; L-ASPARTIC ACID; MATERNAL COCAINE; TERM INFANTS; BLOOD-FLOW; USERS; ABNORMALITIES; METABOLISM; ABUSERS; WITHDRAWAL;
Keywords:
cocaine; prenatal; brain; spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, LM Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Martin Res Ctr, Dept Pediat, 1124 W Carson St, Torrance, CA 90502 USA Univ Calif Los Angeles 1124 W Carson St Torrance CA USA 90502 SA
Citazione:
L.M. Smith et al., "Brain proton magnetic resonance spectroscopy and imaging in children exposed to cocaine in utero", PEDIATRICS, 107(2), 2001, pp. 227-231

Abstract

Objective. The effects of prenatal cocaine exposure have been examined using neurobehavioral and brain structural evaluations; however, no study has examined the effects of prenatal cocaine on brain metabolism. Proton magnetic resonance spectroscopy (H-1-MRS) is a noninvasive method to examine the biochemistry of various brain regions. The purpose of this study was to examine the possible neurotoxic effects of prenatal cocaine exposure on the developing brain using H-1-MRS. Methods. Cocaine-exposed children (n = 14) and age-matched unexposed control participants (n = 12) were evaluated with MRI and localized H-1-MRS. Metabolite concentrations of N-acetyl-containing compounds (NA), total creatine (Cr), choline-containing compounds, myoinositol, and glutamate + glutamine were measured in the frontal white matter and striatum. Results. Despite an absence of structural abnormalities in either group, children exposed to cocaine in utero had significantly higher Cr (+13%) in the frontal white matter. NA, primarily a measure of N-acetyl aspartate and neuronal content, was normal in both regions examined by H-1-MRS. Normal NAsuggests no significant neuronal loss or damage in the 2 brain regions examined in children exposed to cocaine prenatally. Conclusions. Consistent with findings in abstinent adult cocaine users, wefound increased Cr in the frontal white matter, with normal NA in childrenexposed to cocaine. These findings suggest the need to investigate furtherpossible abnormalities of energy metabolism in the brain of children exposed to cocaine in utero. In addition, this study demonstrates the feasibility of using 1(H)-MRS to investigate the effects of prenatal drug exposure onthe developing brain.

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Documento generato il 30/09/20 alle ore 08:57:38