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Titolo:
Difficult asthma: Defining the problems
Autore:
Ranganathan, SC; Payne, DNR; Jaffe, A; McKenzie, SA;
Indirizzi:
Royal London Hosp, London E1 1BB, England Royal London Hosp London England E1 1BB don Hosp, London E1 1BB, England
Titolo Testata:
PEDIATRIC PULMONOLOGY
fascicolo: 2, volume: 31, anno: 2001,
pagine: 114 - 120
SICI:
8755-6863(200102)31:2<114:DADTP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROID-RESISTANT ASTHMA; CORTICOSTEROID-DEPENDENT ASTHMA; GLUCOCORTICOID RECEPTOR-BETA; HOME-ENVIRONMENT; RESPIRATORY SYMPTOMS; PRESCHOOL-CHILDREN; INSENSITIVE ASTHMA; BINDING AFFINITY; CYCLOSPORINE; ASSOCIATION;
Keywords:
difficult asthma; home environment; corticosteroid responsiveness; treatment adherence; compliance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: McKenzie, SA Royal London Hosp, Fielden House, London E1 1BB, England Royal London Hosp Fielden House London England E1 1BB ngland
Citazione:
S.C. Ranganathan et al., "Difficult asthma: Defining the problems", PEDIAT PULM, 31(2), 2001, pp. 114-120

Abstract

A retrospective survey was undertaken of children with difficult asthma, attending a respiratory clinic. The clinical and laboratory profiles of asthmatic children who were poorly controlled on greater than or equal to 800 mug of inhaled corticosteroids (ICS) were studied and compared to children well-controlled on greater than or equal to 800 mug ICS. Assessments were made of atopy, growth, lung function, treatment adherence, home environment, and responsiveness to corticosteroids (CS). Fifty-seven "difficult" and 23 well-controlled children were studied. Significant differences in the home environment were identified. Smoking was significantly more common in the difficult-to-control group. Nine children had alternative diagnoses. Poor CS responsiveness was present in 10 children. Adverse home environments, poor treatment supervision, alternative diagnoses, and unresponsiveness to CS were the most important factors in difficultasthma. A full assessment, including bronchoscopy, is indicated to avoid unnecessary increases in CS to doses that could cause side-effects. Pediatr Pulmonol, 2001; 31:114-120. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/12/19 alle ore 03:56:31