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Titolo:
Activation of metabotropic glutamate receptors inhibits gabaergic transmission in the rat subfornical organ
Autore:
Lee, HS; Chong, W; Han, SK; Lee, MH; Ryu, PD;
Indirizzi:
Seoul Natl Univ, Coll Vet Med, Dept Vet Pharmacol, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 acol, Suwon 441744, South Korea Seoul Natl Univ, Sch Agr Biotechnol, Suwon 441744, South Korea Seoul Natl Univ Suwon South Korea 441744 hnol, Suwon 441744, South Korea
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 102, anno: 2001,
pagine: 401 - 411
SICI:
0306-4522(2001)102:2<401:AOMGRI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; CIRCUMVENTRICULAR ORGANS; SYNAPTIC TRANSMISSION; AMINO-ACIDS; EXTRACELLULAR CONCENTRATION; MAGNOCELLULAR NEURONS; ANGIOTENSIN-II; GRANULE CELLS; BRAIN; PLASMA;
Keywords:
GABA; group II metabotropic glutamate receptor; spontaneous inhibitory postsynaptic current; brain slice; patch clamp; DCG-IV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Ryu, PD Seoul Natl Univ, Coll Vet Med, Dept Vet Pharmacol, 103 Seodun Dong, Suwon 441744, South Korea Seoul Natl Univ 103 Seodun Dong Suwon South Korea 441744 th Korea
Citazione:
H.S. Lee et al., "Activation of metabotropic glutamate receptors inhibits gabaergic transmission in the rat subfornical organ", NEUROSCIENC, 102(2), 2001, pp. 401-411

Abstract

Glutamate is known to increase neuronal excitability in the subfornical organ, a circumventricular organ devoid of the blood-brain barrier. To understand the synaptic mechanism of neuronal excitation by glutamate in this nucleus, we examined the effects of glutamate on GABAergic spontaneous inhibitory postsynaptic currents recorded from subfornical organ neurons in the mtbrain slice. The baseline frequency, amplitude and decay time-constant of such spontaneous synaptic currents were 5.60 Hz, 119 pA and 17.3 ms, respectively. Glutamate (10-1000 muM) selectively inhibited the frequency of spontaneous GABAergic inhibitory postsynaptic currents (half-maximal effective concentration = 47 muM) with little effects on their amplitudes and decay time constants. The inhibitory effect of glutamate on the frequency of spontaneous GABAergic postsynaptic currents was not blocked by tetrodotoxin (1 muM), or by the antagonists of ionotropic glutamate receptors, In contrast, such inhibitory effect of glutamate was mimicked by general or group II selective metabotropic glutamate receptor agonists such as DCGIV (2S,1 'R,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (half-maximal effective concentration = 112 nM), but not by the agonists for group I or group III metabotropic glutamate receptors. Under current clamp mode, glutamate reduced the frequencies of spontaneous inhibitory postsynaptic potentials and action potentials in subfornical organ neurons. Our data indicate that glutamate decreases the frequency of spontaneous inhibitory postsynaptic currents by acting on the group TI metabotropic glutamate receptors on axonal terminals in the subfornical organ. From these results we suggest that the glutamate-induced modulation of tunic GABAergic inhibitory synaptic activity can influence the excitability of subfornical organ neurons. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:35:16