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Titolo:
Glutamatergic regulation of haloperidol-induced c-fos expression in the rat striatum and nucleus accumbens
Autore:
Hussain, N; Flumerfelt, BA; Rajakumar, N;
Indirizzi:
Univ Western Ontario, Dept Anat & Cell Biol, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada London Hlth Sci Ctr, Dept Psychiat, London, ON N6A 5A5, Canada London HlthSci Ctr London ON Canada N6A 5A5 , London, ON N6A 5A5, Canada
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 102, anno: 2001,
pagine: 391 - 399
SICI:
0306-4522(2001)102:2<391:GROHCE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; BASAL GANGLIA; VENTRAL STRIATUM; TOPOGRAPHICAL ORGANIZATION; COMPARTMENTAL ORGANIZATION; DIFFERENTIAL EXPRESSION; EFFERENT PROJECTIONS; SUBUNIT COMPOSITION; DOPAMINE-RECEPTORS; NEURONS;
Keywords:
haloperidol; NMDA; c-fos; extrapyramidal symptoms; striatum; nucleus accumbens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Rajakumar, N Univ Western Ontario, Dept Anat & Cell Biol, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 6A 5C1, Canada
Citazione:
N. Hussain et al., "Glutamatergic regulation of haloperidol-induced c-fos expression in the rat striatum and nucleus accumbens", NEUROSCIENC, 102(2), 2001, pp. 391-399

Abstract

Acute administration of haloperidol induces the expression of the immediate-early gene c-fos in the striatum and nucleus accumbens via dopamine D-2 receptor antagonism. Dopaminergic transmission in the striatum and nucleus accumbens is modulated by glutamate via N-methyl-D-aspartate (NMDA) receptors. Indeed, haloperidol-induced c-fos expression is dependent on NMDA receptor activation in the dorsolateral part of the striatum. However, the role that NMDA receptors play in haloperidol-induced c-fos expression in other functionally distinct areas of the striatum and nucleus accumbens has not yetbeen established. Therefore, in the present study the entire rostrocaudal extent of the rat striatum and nucleus accumbens was examined to determine the role that NMDA receptors play in haloperidol-induced c-fos expression. Pretreatment with MK-801, a non-competitive antagonist of NMDA receptors, significantly reduced the number of neurons showing c-fos immunoreactivity in the rostral aspect of the dorsolateral striatum and the entire rostrocaudal extent of the ventrolateral striatum following an acute injection of haloperidol. However, the same treatment did not modify the pattern of haloperidol-mediated c-fos expression in the medial or central parts of the striatum. Similarly, MK-801 pretreatment significantly suppressed the number of neurons expressing c-fos immunoreactivity following haloperidol injection inthe entire rostrocaudal extent of the shell region of nucleus accumbens, but not in the core region. The results indicate that haloperidol-induced c-fos expression is dependent on NMDA receptors only in the rostral aspect of the dorsolateral striatumand the rostrocaudal extent of the ventrolateral striatum, the areas involved in motor function. The differential role that NMDA receptors play in modulating haloperidol-mediated dopamine D-2 receptor antagonism between motor and associative areas of the striatum may contribute to the development of extrapyramidal symptoms following chronic haloperidol treatment. Furthermore, the attenuation of the haloperidol-induced c-fos expression by MK-801 was restricted to the nucleus accumbens shell, an area often implicated in the therapeutic effect of haloperidol. Therefore, the NMDA-dopamine D-2 receptor interaction may also play a role in mediating the therapeutic effectsof haloperidol. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:30:27