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Titolo:
Reproductive status influences cell proliferation and cell survival in thedentate gyrus of adult female meadow voles: A possible regulatory role forestradiol
Autore:
Ormerod, BK; Galea, LAM;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada Univ British Columbia, Grad Program Neurosci, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 102, anno: 2001,
pagine: 369 - 379
SICI:
0306-4522(2001)102:2<369:RSICPA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ACTIVATION; DENDRITIC SPINE DENSITY; CENTRAL-NERVOUS-SYSTEM; MICROTUS-PENNSYLVANICUS; HIPPOCAMPAL-NEURONS; ESTROUS-CYCLE; GRANULE CELLS; ADRENAL-STEROIDS; RAT HIPPOCAMPUS; PRAIRIE VOLES;
Keywords:
adult neurogenesis; granule neurons; corticosterone; bromodeoxyuridine; (3)[H]thymidine; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Ormerod, BK Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T1Z4
Citazione:
B.K. Ormerod e L.A.M. Galea, "Reproductive status influences cell proliferation and cell survival in thedentate gyrus of adult female meadow voles: A possible regulatory role forestradiol", NEUROSCIENC, 102(2), 2001, pp. 369-379

Abstract

Galca and McEwen [Galea and McEwan (1999) Neuroscience 89, 955-964] found that cell proliferation was suppressed in female meadow voles trapped during the breeding season relative to females trapped during the non-breeding season. We investigated the effect of reproductive status and estradiol level on cell proliferation and cell survival in adult laboratory-reared femalemeadow voles to control for the variables of age, experience and pregnancythat could confound the results derived from a wild sample. Voles were housed in either a long- or short-photoperiod to simulate season and a male orfemale cage partner was introduced to influence reproductive status. Because females are reflex ovulators, exposure to a male rapidly induces behavioural estrous and high levels of estradiol. Forty-eight hours after introducing a cage partner, we injected either bromodeoxyuridine or [H-3]thymidine to mark cell synthesis and then examined labelled cells 2 h (cell proliferation) or five weeks (cell survival) later, respectively. To determine whether estradiol mimicked the effect of reproductive status, groups of reproductively inactive females were given a single injection of estradiol benzoate(10 mug) either four or 48 h prior to bromodeoxyuridine labelling. The density of proliferating cells in the granule cell layer and the hilus was elevated in reproductively inactive females compared to reproductively active females and was correlated negatively with serum estradiol level. Exposure to estradiol benzoate initially increased cell proliferation (within 4 h) but subsequently suppressed cell proliferation (within 48 h). In addition, the density of surviving cells was greater in reproductively inactive females relative to reproductively active females but reproductively active females had a greater rate of cell survival than did reproductively inactive females. Reproductive status did not influence the number of pyknotic cells inthe dentate gyrus (at either 2 h or five weeks). We conclude that reproductive status regulates cell proliferation in adultfemale meadow voles, possibly via an estradiol-regulated mechanism. The results from the present study showed that reproductively active female meadow voles have suppressed rates of cell proliferation in the dentate gyrus relative compared with reproductively inactive female meadow voles. Administering estradiol initially (within 4 h) elevates the cell proliferation within the dentate gyrus of adult females but subsequently (within 48 h) suppresses cell proliferation. However, more neu cells survived in females with high endogenous levels of estradiol (reproductively active females). In conclusion, reproductive status regulates the level of cell proliferation and survival through a complex estradiol regulated mechanism(s). (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 12:11:56