Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Subicular lesions cause dendritic atrophy in CA1 and CA3 pyramidal neuronsof the rat hippocampus
Autore:
Rao, BSS; Govindaiah; Laxmi, TR; Meti, BL; Raju, TR;
Indirizzi:
Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029 , India
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 102, anno: 2001,
pagine: 319 - 327
SICI:
0306-4522(2001)102:2<319:SLCDAI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATION REWARDING EXPERIENCE; RETROHIPPOCAMPAL LESIONS; IBOTENATE LESIONS; MEMORY IMPAIRMENT; SPATIAL MEMORY; MOTOR CORTEX; MAZE TASK; PERFORMANCE; REGION; CONNECTIONS;
Keywords:
ventral subiculum; hippocampal formation; dendritic atrophy; ibotenate lesions; Golgi impregnation; behavioral deficits;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Raju, TR Natl Inst Mental Hlth & Neurosci, Dept Neurophysiol, POB 2900,Hosur Rd, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci POB 2900,Hosur Rd Bangalore Karnataka India 560029
Citazione:
B.S.S. Rao et al., "Subicular lesions cause dendritic atrophy in CA1 and CA3 pyramidal neuronsof the rat hippocampus", NEUROSCIENC, 102(2), 2001, pp. 319-327

Abstract

The subiculum is a major source of output projections from hippocampus to cortical and subcortical regions. Our previous studies have demonstrated the selective loss of CA1 pyramidal neurons of the hippocampus, and operant and spatial learning impairment in subicular lesioned rats [Govindaiah et al. (1997) Brain Res. 745, 121-126; Laxmi et al. (1999) Brain Res. 816, 245-148]. In the present study, the effect of ibotenate lesions of the subiculumon the dendritic morphology of CA1 and CA3 pyramidal neurons of the hippocampus was investigated in 30-day-old male Wistar rats. The ventral subiculum was lesioned bilaterally with multiple injections of ibotenic acid, stereotaxically. The dendritic branching points and intersections were studied in apical and basal dendrites up to 320 and 160 mum, respectively, in Golgi-impregnated CA1 and CA3 pyramidal neurons of the hippocampus. The results revealed a significant (P < 0.001) decrease in the number of dendritic branching points, intersections and total number of dendrites in both apical andbasal dendrites of CA1, as well as CA3 pyramidal neurons of the hippocampus. It is surprising that the subicular lesions caused dendritic atrophy of CA3 neurons without affecting the cell density. The results of the present study demonstrate the dendritic atrophy of hippocampal neurons following selective subicular lesions. This might be responsible fur the impairments in operant and spatial learning tasks in these rats as observed in our earlier studies, In addition, hippocampal damage is also associated with an impairment in the process of the active monitoring of movements in space, rather than place learning per se [Whishaw (1998) Neurosci. biobeh. Rev. 22, 209-220]. Accordingly, further studies are requiredto correlate the differential effect of subicular lesions on impairments learning and movement in space in rats, (C) 2001 IBRO. Published by ElsevierScience Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:19:59