Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo
Autore:
Commins, S; ONeill, LAJ; OMara, SM;
Indirizzi:
Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Biochem, Dublin 2, Ireland
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 102, anno: 2001,
pagine: 273 - 280
SICI:
0306-4522(2001)102:2<273:TEOTBE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; GYRUS IN-VITRO; PAIRED-PULSE FACILITATION; HIPPOCAMPAL AREA CA1; NEURONAL LOCALIZATION; MOUSE-BRAIN; RAT; INTERLEUKIN-1-BETA; RECEPTORS; SUBICULUM;
Keywords:
lipopolysaccharide; synaptic plasticity; subiculum; cytokines; hippocampus; synaptic transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: O'Mara, SM Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 , Dublin 2, Ireland
Citazione:
S. Commins et al., "The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo", NEUROSCIENC, 102(2), 2001, pp. 273-280

Abstract

Lipopolysaccharide is derived from the cell wall of gram-negative bacteriaand is a potent endotoxin which causes the release of cytokines in the CNS. We examined the effect of lipopolysaccharide on synaptic transmission andsynaptic plasticity in the hippocampal area CA1-subicular pathway in vivo. We found that lipopolysaccharide did not affect baseline synaptic transmission in this pathway; it did, however, reduce the magnitude of paired-pulsefacilitation, a form of short-term plasticity thought to be primarily presynaptic in origin. We then examined the interaction between lipopolysaccharide and two common models for the biological basis of memory: high-frequency stimulation induced long-term potentiation and low frequency stimulation induced long-term depression of synaptic transmission. We found that lipopolysaccharide blocked long-term potentiation following high-frequency stimulation and also induced potentiation of synaptic transmission after low-frequency stimulation. Lipolysaccharide blocked paired-pulse facilitation selectively at short rattler than longer interstimulus intervals. Thus, lipopolysaccharide has different effects on synaptic transmission in this pathway depending on the frequency and length of stimulation. These results provide new insights into the action of lipopolysaccharide on various forms of plasticity in dir hippocampus. an area known to play a vital role in learning and memory. (C) 2001 IBRO. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:11:04