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Titolo:
First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice
Autore:
Beracochea, D; Cagnard, B; Celerier, A; le Merrer, J; Peres, M; Pierard, C;
Indirizzi:
Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5601, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 UMR 5601, F-33405 Talence, France Serv Sante Armees, Inst Med Aerospatiale, Bretigny Sur Orge, France Serv Sante Armees Bretigny Sur Orge France e, Bretigny Sur Orge, France
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 12, anno: 2001,
pagine: 375 - 378
SICI:
0959-4965(20010212)12:2<375:FEOADW>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGENT MODAFINIL; RAT; AMPHETAMINE; DRUG; PERFORMANCE; PLACEBO;
Keywords:
alternation; modafinil; mouse; working memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Beracochea, D Univ Bordeaux 1, Cognit Neurosci Lab, CNRS, UMR 5601, Ave Fac, F-33405 Talence, France Univ Bordeaux 1 Ave Fac Talence France F-33405 ence, France
Citazione:
D. Beracochea et al., "First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice", NEUROREPORT, 12(2), 2001, pp. 375-378

Abstract

This study investigated the effects of pretest injection of modafinil on delayed spontaneous alternation rates (SA) used to evaluate working memory in C57 BI/6 mice. In a first experiment, systemic modafinil at 64 mg/kg, butnot at 8 mg/kg or 32 mg/kg doses produced a significant increase of alternation scores (intertrial interval (ITI) 60s) when compared with controls. In a second experiment, modafinil (64 mg/kg) enhanced the alternation rates mainly at long (60 s and 180 s) but not at short (5s) ITIs. Exploratory latencies and activity in a four hole-board apparatus were not modified by modafinil administration. These experiments are the first to demonstrate a delay-dependent working memory-enhancing effect of modafinil. NeuroReport 12:375-378 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 29/03/20 alle ore 08:58:17