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Titolo:
The effects of propofol on NMDA- or nitric oxide-mediated neurotoxicity invitro
Autore:
Shibuta, S; Sriranganathan, V; Inoue, T; Shimizu, T; Tomi, K; Mashimo, T;
Indirizzi:
Osaka Univ, Sch Med, Dept Anesthesiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 thesiol, Suita, Osaka 5650871, Japan Toyonaka Municipal Hosp, Osaka, Japan Toyonaka Municipal Hosp Osaka Japan yonaka Municipal Hosp, Osaka, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 12, anno: 2001,
pagine: 295 - 298
SICI:
0959-4965(20010212)12:2<295:TEOPON>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; PRIMARY BRAIN CULTURES; PEROXYNITRITE SCAVENGER; THERMAL HYPERALGESIA; HIPPOCAMPAL-NEURONS; CELL-CULTURES; SUPEROXIDE; RAT; NOC-18; INHIBITION;
Keywords:
nitric oxide; NMDC; NOC; primary cultured neurons; propofol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shibuta, S Osaka Univ, Sch Med, Dept Anesthesiol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 50871, Japan
Citazione:
S. Shibuta et al., "The effects of propofol on NMDA- or nitric oxide-mediated neurotoxicity invitro", NEUROREPORT, 12(2), 2001, pp. 295-298

Abstract

Acute brain ischemia causes neurotoxic cascades including NMDA receptors and NO. Propofol, an i.v, anesthetic, is thought to have a neuroprotective effect. We investigated the influence of propofol on NMDA/NO neurotoxicity using Shibuta's established model of primary brain cultures. Cortical neurons prepared from E16 were used after 13-14 days in culture. The neurons wereexposed to various concentrations of propofol with NMDA or NO-donor. The survival rates of neurons exposed to 30 muM NMDA with or without 300 muM propofol were 12.1 +/- 2.2% and 11.9 +/- 2.2%, respectively. The survival rates exposed to 30 muM NO-donor with or without 300 muM propofol were 11.2 +/-4.2% and 14.0 +/- 3.9%, respectively. These results suggest that neuroprotective effect of propofol is limited and propofol does not offer advantagesover thiopental against NMDA/NO-induced cytotoxicity. NeuroReport 12:295-298 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 26/01/20 alle ore 16:08:24