Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ibogaine alters synaptosomal and glial glutamate release and uptake
Autore:
Leal, MB; Emanuelli, T; Porciuncula, LD; Souza, DO; Elisabetsky, E;
Indirizzi:
Univ Fed Rio Grande Sul, ICBS, Pos Grad Ciencias Biol, BR-90041970 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90041970 BC, RS, Brazil Univ Fed Rio Grande Sul, ICBS, Dept Farmacol, BR-90041970 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-90041970 BC, RS, Brazil Univ Fed Santa Maria, CCR, Dept Tecnol & Ciencia Alimentos, BR-97119900 Santa Maria, RS, Brazil Univ Fed Santa Maria Santa Maria RS Brazil BR-97119900 BCaria, RS, Brazil
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 12, anno: 2001,
pagine: 263 - 267
SICI:
0959-4965(20010212)12:2<263:IASAGG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; PURKINJE-CELLS; DRUG; RECEPTORS; NEURODEGENERATION; MECHANISMS; DEPENDENCE; FRACTION; AFFINITY; BINDING;
Keywords:
astrocyte; glutamate; ibogaine; mice; rats; release; synaptosomes; uptake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Elisabetsky, E Univ Fed Rio Grande Sul, ICBS, Pos Grad Ciencias Biol, CP 5072, BR-90041970 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul CP 5072 Porto Alegre RS Brazil BR-90041970 BC
Citazione:
M.B. Leal et al., "Ibogaine alters synaptosomal and glial glutamate release and uptake", NEUROREPORT, 12(2), 2001, pp. 263-267

Abstract

Ibogaine has aroused expectations as a potentially innovative medication for drug addiction. It has been proposed that antagonism of the NMDA receptor by ibogaine may be one of the mechanisms underlying its antiaddictive properties; glutamate has also been implicated in ibogaine-induced neurotoxicity. We here report the effects of ibogaine on [H-3]glutamate release and uptake in cortical and cerebellar synaptosomes, as well as in cortical astrocyte cultures, from mice and rats. Ibogaine (2-1000 muM) had no effects on glutamate uptake or release by rat synaptosomes. However, ibogaine (500-1000muM) significantly inhibited the glutamate:uptake and stimulated the release of glutamate by cortical (but not cerebellar) synaptosomes of mice. In addition,ibogaine (1000 muM) nearly abolished glutamate uptake by cortical astrocyte cultures from rats and mice. The data provide direct evidence of glutamate involvement in ibogaine-induced neurotoxicity. NeuroReport 12:263-267 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:49:31