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Titolo:
Natriuretic peptides inhibit apoptosis and prolong the survival of serum-deprived PC12 cells
Autore:
Fiscus, RR; Tu, AWK; Chew, SBC;
Indirizzi:
Chinese Univ Hong Kong, Fac Med, Epithelial Cell Biol Res Ctr, Dept Physiol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Ctr Gerontol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Ctr Geriatr, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 12, anno: 2001,
pagine: 185 - 189
SICI:
0959-4965(20010212)12:2<185:NPIAAP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTICULATE GUANYLATE-CYCLASE; DEPENDENT PROTEIN-KINASE; ELEVATES CYCLIC-GMP; RAT THORACIC AORTA; NITRIC-OXIDE; MEDIATED MECHANISM; CGMP; NEURONS; DEATH; PHEOCHROMOCYTOMA;
Keywords:
apoptosis; atrial natriuretic peptide; brain natriuretic peptide; cell survival; cGMP; DNA fragmentation; neural cell; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Fiscus, RR Chinese Univ Hong Kong, Fac Med, Epithelial Cell Biol Res Ctr, Dept Physiol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China China
Citazione:
R.R. Fiscus et al., "Natriuretic peptides inhibit apoptosis and prolong the survival of serum-deprived PC12 cells", NEUROREPORT, 12(2), 2001, pp. 185-189

Abstract

Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were investigated to determine effects on apoptotic DNA fragmentation and survival in serum-deprived PC 12 cells. Both peptides caused prolonged cGMP (but not cAMP) elevations lasting for greater than or equal to 6 h. The cGMP elevations were 10-, 50- and 68-fold for ANP and 26-, 100- and 148-fold for BNP at 1, 10 and 100 nM, respectively. BNP caused dose-dependent increases incell survival rates during 3 days of serum deprivation. BNP (1 nM) increased 24 h survival rate from 36% to 67%. ANP(1 nM), BNP (1 nM) and 8-bromo-cGMP (0.1 mM) inhibited by 74.8%, 46.7% and 8.8%, respectively, the apoptoticDNA fragmentation in serum-deprived PC12 cells, measured by our recently developed quantitative technique using capillary electrophoresis with laser-induced fluorescence detector (CE-LIF). The data suggest prolonged cGMP elevations caused by ANP or BNP inhibit apoptotic DNA fragmentation and prolong the survival of serum-deprived PC12 cells. Neuro-Report 12:185-189 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:42:48