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Titolo:
Transport of endosomal early antigen I in the rat sciatic nerve and location in cultured neurons
Autore:
Bartlett, SE; Reynolds, AJ; Weible, M; Noakes, PG; Hendry, IA;
Indirizzi:
Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Dev NeurobiolGrp, Canberra, ACT 2601, Australia Australian Natl Univ Canberra ACT Australia 2601 rra, ACT 2601, Australia Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld, Australia Univ Queensland St Lucia Qld Australia armacol, St Lucia, Qld, Australia
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 12, anno: 2001,
pagine: 281 - 284
SICI:
0959-4965(20010212)12:2<281:TOEEAI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE TRANSPORT; RAB5 EFFECTORS; PROTEIN; REGENERATION; ENDOCYTOSIS; AXOPLASM; EEA1;
Keywords:
anterograde transport; axonal transport; DRG; EEAI; nerve injury; SCG; sciatic nerve; sensory neurons; sympathetic neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Bartlett, SE Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Dev NeurobiolGrp, GPO Box 334, Canberra, ACT 2601, Australia Australian Natl Univ GPO Box 334 Canberra ACT Australia 2601
Citazione:
S.E. Bartlett et al., "Transport of endosomal early antigen I in the rat sciatic nerve and location in cultured neurons", NEUROREPORT, 12(2), 2001, pp. 281-284

Abstract

Early endosomal antigen I (EEAI) is known to be a marker of early endosomes and in cultured hippocampal neurons it preferentially localizes to the dendritic but not the axonal compartment. We show in cultured dorsal root ganglia and superior cervical ganglia neurons that EEAI localizes to the cell bodies and the neurites of both sensory and sympathetic neurons. We then show in vivo using a ligated rat sciatic nerve that EEAI significantly accumulates on the proximal side and not on the distal side of the ligation. Thissuggests that EEAI is transported in the anterograde direction in axons either as part of the homeostatic process or to the nerve ligation site in response to nerve injury. NeuroReport 12:281-284 (C) 2001 Lippincott Williams& Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:34:39