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Titolo:
LIF is more potent than BDNF In promoting neurite outgrowth of mammalian auditory neurons in vitro
Autore:
Gillespie, LN; Clark, GM; Bartlett, PF; Marzella, PL;
Indirizzi:
Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, E Melbourne 3002, Australia Univ Melbourne E Melbourne Australia 3002 l, E Melbourne 3002, Australia Walter & Eliza Hall Inst Med Res, Dev & Neurobiol Lab, Parkville, Vic 3052, Australia Walter & Eliza Hall Inst Med Res Parkville Vic Australia 3052 , Australia
Titolo Testata:
NEUROREPORT
fascicolo: 2, volume: 12, anno: 2001,
pagine: 275 - 279
SICI:
0959-4965(20010212)12:2<275:LIMPTB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA INHIBITORY FACTOR; IN-VITRO; NEUROTROPHIC FACTOR; GANGLION NEURONS; SCHWANN-CELLS; INNER-EAR; SURVIVAL; INNERVATION; RECEPTORS; NT-3;
Keywords:
auditory; BDNF; LIF; mammalian; neurite outgrowth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gillespie, LN Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Otolaryngol, 32 Gisborne St, E Melbourne 3002, Australia Univ Melbourne 32 Gisborne St E Melbourne Australia 3002 ia
Citazione:
L.N. Gillespie et al., "LIF is more potent than BDNF In promoting neurite outgrowth of mammalian auditory neurons in vitro", NEUROREPORT, 12(2), 2001, pp. 275-279

Abstract

Neurotrophic factors are known to play a crucial role in the elongation and guidance of auditory nerve fibres to their targets within the organ of Corti. Maintenance of these neural connections following deafness would clearly influence the efficacy of therapies for hearing recovery. The growth factors leukaemia inhibitory factor (LIF), brain-derived neurotrophic factor (BDNF) and transforming growth factor-beta 5 (TGF-beta5) were tested for their efficacy in promoting neurite outgrowth from dissociated cultures of early postnatal rat auditory neurons. Our results indicate that while BDNF enhances neurite outgrowth in a strong fashion, LIF is more potent; moreover, the combined administration of both factors has even greater neuritogenic capacities. TGF-beta5, although neurotrophic, has no neuritogenic activity on cultured auditory neurons. LIF and BDNF may therefore be potential candidates when developing pharmacological therapies for hearing recovery. NeuroReport 12:275-279 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 10:20:46