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Titolo:
Kainate receptors are involved in short- and long-term plasticity at mossyfiber synapses in the hippocampus
Autore:
Contractor, A; Swanson, G; Heinemann, SF;
Indirizzi:
Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 29, anno: 2001,
pagine: 209 - 216
SICI:
0896-6273(200101)29:1<209:KRAIIS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; SYNAPTIC TRANSMISSION; GLUR6-DEFICIENT MICE; CA3 NEURONS; LATE-PHASE; POTENTIATION; ACTIVATION; LTP; RESPONSES; FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Contractor, A Salk Inst Biol Studies, Mol Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
A. Contractor et al., "Kainate receptors are involved in short- and long-term plasticity at mossyfiber synapses in the hippocampus", NEURON, 29(1), 2001, pp. 209-216

Abstract

Kainate receptors alter the excitability of mossy fiber axons and have been reported to play a role in the induction of long-term potentiation (LTP) at mossy fiber synapses in the hippocampus. These previous studies have relied primarily on the use of compounds whose selectivity is unclear. In thisreport, we investigate short- and long-term facilitation of mossy fiber synaptic transmission in kainate receptor knockout mice. We find that LTP is reduced in mice lacking the GluR6, but not the GluR5, kainate receptor subunit. Additionally, short-term synaptic facilitation is impaired in GluR6 knockout mice, suggesting that kainate receptors act as presynaptic autoreceptors on mossy fiber terminals to facilitate synaptic transmission. These data demonstrate that kainate receptors containing the GluR6 subunit are important modulators of mossy fiber synaptic strength.

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Documento generato il 02/04/20 alle ore 06:27:36