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Titolo:
Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline
Autore:
Yokoyama, N; Romero, MI; Cowan, CA; Galvan, P; Helmbacher, F; Charnay, P; Parada, LF; Henkemeyer, M;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 ed Ctr, Ctr Dev Biol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Kent Waldrep Fdn, Ctr Basic Res Nerve Growth & Regenerat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 e Growth & Regenerat, Dallas, TX 75390 USA Ecole Normale Super, INSERM, U368, F-75231 Paris, France Ecole Normale Super Paris France F-75231 RM, U368, F-75231 Paris, France
Titolo Testata:
NEURON
fascicolo: 1, volume: 29, anno: 2001,
pagine: 85 - 97
SICI:
0896-6273(200101)29:1<85:FSMBEP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL PATTERN GENERATORS; RECEPTOR TYROSINE KINASES; EMBRYONIC STEM-CELLS; EPH RECEPTORS; MIRROR MOVEMENTS; TRANSMEMBRANE LIGANDS; KALLMANNS-SYNDROME; TRANSGENIC MICE; TRACT; LOCOMOTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Henkemeyer, M Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 v Biol, Dallas, TX 75390 USA
Citazione:
N. Yokoyama et al., "Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline", NEURON, 29(1), 2001, pp. 85-97

Abstract

To investigate Eph-ephrin bidirectional signaling, a series of mutations were generated in the ephrin-B3 locus. The absence of both forward and reverse signaling resulted in mice with mirror movements as typified by a hopping locomotion. The corticospinal tract was defective as axons failed to respect the midline boundary of the spinal cord and bilaterally innervated bothcontralateral and ipsilateral motor neuron populations. A second mutation that expresses a truncated ephrin-B3 protein lacking its cytoplasmic domaindid not lead to hopping, indicating that reverse signaling is not requiredfor corticospinal innervation. Ephrin-B3 is concentrated at the spinal cord midline, while one of its receptors, EphA4, is expressed in postnatal corticospinal neurons as their fibers pathfind down the contralateral spinal cord. Our data indicate ephrin-B3 functions as a midline-anchored repellent to stimulate forward signaling in EphA4-expressing axons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:36:51