Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurotransmitter distribution in the second trimester fetal human corpus striatum
Autore:
Barami, K; Hutchins, KD; Lyman, WD;
Indirizzi:
Wayne State Univ, Ctr Hlth 6E, Dept Neurosurg, Detroit, MI 48201 USA WayneState Univ Detroit MI USA 48201 pt Neurosurg, Detroit, MI 48201 USA Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA Albert EinsteinColl Med Bronx NY USA 10467 t Pathol, Bronx, NY 10467 USA Childrens Hosp Michigan, Childrens Res Ctr, Detroit, MI 48201 USA Childrens Hosp Michigan Detroit MI USA 48201 s Ctr, Detroit, MI 48201 USA Wayne State Univ, Detroit Med Ctr, Dept Pediat, Detroit, MI 48202 USA Wayne State Univ Detroit MI USA 48202 Dept Pediat, Detroit, MI 48202 USA
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 1, volume: 23, anno: 2001,
pagine: 16 - 22
SICI:
0161-6412(200101)23:1<16:NDITST>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUNTINGTONS-DISEASE; LESIONED STRIATUM; BASAL GANGLIA; CHOREA; ACID; GRAFTS; MODEL; TRANSPLANTATION; RIGIDITY; NEURONS;
Keywords:
Corpus striatum; development; Huntington's disease; human fetus; immunocytochemistry; neuron; neurotransmitter; second trimester;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Barami, K Wayne State Univ, Ctr Hlth 6E, Dept Neurosurg, 4201 St Antoine St,, Detroit, MI 48201 USA Wayne State Univ 4201 St Antoine St, Detroit MI USA 48201 01 USA
Citazione:
K. Barami et al., "Neurotransmitter distribution in the second trimester fetal human corpus striatum", NEUROL RES, 23(1), 2001, pp. 16-22

Abstract

One experimental strategy that may offer hope in the neurodegenerative disorder Huntington's disease (HD) has been neural transplantation. In HD, most of the pathological changes occur in the corpus striatum. Fetal human striatal implants will most likely be the first transplant strategy attempted in clinical trials to replace lost neurons and/or prevent the degeneration of neurons destined to die. The temporal expression of neurotransmitters inthe developing human corpus striatum is a key factor in determining the optimum age of transplantable tissue. To this end, an immunocytochemical analysis of various neurotransmitters was performed on second trimester human brains. Antibodies against acetylcholine, gamma-aminobutyric acid, enkephalin, neuropeptide-Y and substance P were used in ten human fetal brains ranging from 13 to 21 weeks gestation. The presence and pattern of distribution for these neurotransmitters varied in the different parts of the corpus striatum (globus pallidus, putamen, caudate nucleus). These results are compared to the already existing data for the adult human corpus striatum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:57:34