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Titolo:
Detecting and estimating signals over noisy and unreliable synapses: Information-theoretic analysis
Autore:
Manwani, A; Koch, C;
Indirizzi:
CALTECH, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Pasadena, CA 91125 USA
Titolo Testata:
NEURAL COMPUTATION
fascicolo: 1, volume: 13, anno: 2001,
pagine: 1 - 33
SICI:
0899-7667(200101)13:1<1:DAESON>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; NEOCORTICAL PYRAMIDAL NEURONS; CULTURED HIPPOCAMPAL-NEURONS; TIME-VARYING SIGNALS; SYNAPTIC TRANSMISSION; QUANTAL ANALYSIS; SPIKE TRAINS; RELEASE PROBABILITY; TRANSMITTER RELEASE; CABLE STRUCTURES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Manwani, A CALTECH, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Pasadena, CA 91125 USA
Citazione:
A. Manwani e C. Koch, "Detecting and estimating signals over noisy and unreliable synapses: Information-theoretic analysis", NEURAL COMP, 13(1), 2001, pp. 1-33

Abstract

The temporal precision with which neurons respond to synaptic inputs has adirect bearing on the nature of the neural code. A characterization of theneuronal noise sources associated with different sub-cellular components (synapse, dendrite, soma, axon, and so on) is needed to understand the relationship between noise and information transfer. Here we study the effect ofthe unreliable, probabilistic nature of synaptic transmission on information transfer in the absence of interaction among presynaptic inputs. We derive theoretical lower bounds on the capacity of a simple model of a corticalsynapse under two different paradigms. In signal estimation, the signal isassumed to be encoded in the mean firing rate of the presynaptic neuron, and the objective is to estimate the continuous input signal from the postsynaptic voltage. In signal detection, the input is binary, and the presence or absence of a presynaptic action potential is to be detected from the postsynaptic voltage. The efficacy of information transfer in synaptic transmission is characterized by deriving optimal strategies under these two paradigms. On the basis of parameter values derived from neocortex, we find thatsingle cortical synapses cannot transmit information reliably, but redundancy obtained using a small number of multiple synapses leads to a significant improvement in the information capacity of synaptic transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:25:53