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Titolo:
Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines
Autore:
Sinkkonen, ST; Mihalek, RM; Homanics, GE; Luddens, H; Korpi, ER;
Indirizzi:
Univ Turku, Dept Pharmacol & Clin Pharmacol, FIN-20520 Turku, Finland UnivTurku Turku Finland FIN-20520 n Pharmacol, FIN-20520 Turku, Finland Univ Turku, Turku Grad Sch Biomed Sci, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Biomed Sci, FIN-20520 Turku, Finland Univ Pittsburgh, Sch Med, Dept Anesthesiol Crit Care Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 are Med, Pittsburgh, PA 15261 USA Univ Mainz, Dept Psychiat, Clin Res Grp, D-6500 Mainz, Germany Univ MainzMainz Germany D-6500 iat, Clin Res Grp, D-6500 Mainz, Germany
Titolo Testata:
MOLECULAR BRAIN RESEARCH
fascicolo: 1-2, volume: 86, anno: 2001,
pagine: 179 - 183
SICI:
0169-328X(20010131)86:1-2<179:AACOGT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
A RECEPTOR; ACID(A) RECEPTORS; DELTA-SUBUNIT; HIGH-AFFINITY; RAT-BRAIN; PHARMACOLOGY; SENSITIVITY; KNOCKOUT; MICE;
Keywords:
GABA(A) receptor; [S-35]TBPS binding; receptor heterogeneity; receptor subunit; knockout mouse line;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Korpi, ER Univ Turku, Dept Pharmacol & Clin Pharmacol, Kiinamyllynkatu 10,FIN-20520Turku, Finland Univ Turku Kiinamyllynkatu 10 Turku Finland FIN-20520 , Finland
Citazione:
S.T. Sinkkonen et al., "Altered atypical coupling of gamma-aminobutyrate type A receptor agonist and convulsant binding sites in subunit-deficient mouse lines", MOL BRAIN R, 86(1-2), 2001, pp. 179-183

Abstract

We searched for subunit correlations for GABA(A) receptor-associated atypically GABA-insensitive [S-35]TBPS binding. The homomeric beta3 subunit receptors could be excluded, as GABA-insensitive [S-35]TBPS binding was presentin beta3-/- mice. Localization of GABA-insensitive [S-35]TBPS binding correlated best with those of delta, alpha4 and alpha6 subunit mRNAs. The amounts of GABA-insensitive [S-35]TBPS binding components were increased in delta-/- mice, but dramatically reduced in alpha6-/- mice, suggesting a role for alpha6 but excluding delta subunits. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:50:50