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Titolo:
Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrixglycoprotein tenascin-R
Autore:
Saghatelyan, AK; Dityatev, A; Schmidt, S; Schuster, T; Bartsch, U; Schachner, M;
Indirizzi:
Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 Neurobiol, D-20246 Hamburg, Germany
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 1, volume: 17, anno: 2001,
pagine: 226 - 240
SICI:
1044-7431(200101)17:1<226:RPIIET>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL RECOGNITION MOLECULES; CELL-ADHESION MOLECULES; SYNAPTIC PLASTICITY; IN-VITRO; HIPPOCAMPAL-NEURONS; SILENT SYNAPSES; RAT HIPPOCAMPUS; NERVOUS-SYSTEM; MESSENGER-RNA; ADULT-MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Schachner, M Univ Hamburg, Zentrum Mol Neurobiol, Martinistr 52, D-20246 Hamburg, Germany Univ Hamburg Martinistr 52 Hamburg Germany D-20246 , Germany
Citazione:
A.K. Saghatelyan et al., "Reduced perisomatic inhibition, increased excitatory transmission, and impaired long-term potentiation in mice deficient for the extracellular matrixglycoprotein tenascin-R", MOL CELL NE, 17(1), 2001, pp. 226-240

Abstract

The role of the extracellular matrix molecule tenascin-R (TN-R) in regulation of synaptic transmission and plasticity in the CA1 region of the hippocampus was studied using mice deficient in expression of this molecule. The mutant mice showed normal NM DA-receptor-mediated currents but an impaired NM DA-receptor-dependent form of long-term potentiation (LTP) as compared to wildtype littermates. Reduced LTP in mutants was accompanied by increasedbasal excitatory synaptic transmission in synapses formed on CA1 pyramidalneurons. A possible mechanism for increased excitatory synaptic transmission in mutants could involve modulation of inhibition, since TN-R and its associated carbohydrate HNK-1 decorate perisomatic interneurons. Indeed, the amplitudes of unitary perisomatic inhibitory currents were smaller in mutants compared to wild-type mice. Thus, our data show that a deficit in TN-R results in reduction of perisomatic inhibition and, as a consequence, in an increase of excitatory synaptic transmission in CA1 to the levels close to saturation, impeding further expression of LTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:19:12