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Titolo:
A novel mechanism for modulating synaptic gene expression: Differential localization of alpha-dystrobrevin transcripts in skeletal muscle
Autore:
Newey, SE; Gramolini, AO; Wu, J; Holzfeind, P; Jasmin, BJ; Davies, KE; Blake, DJ;
Indirizzi:
Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England Univ Oxford Oxford England OX1 3QX t Genet Unit, Oxford OX1 3QX, England Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada Univ Ottawa Ottawa ON Canada K1H 8M5 Mol Med, Ottawa, ON K1H 8M5, Canada
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 1, volume: 17, anno: 2001,
pagine: 127 - 140
SICI:
1044-7431(200101)17:1<127:ANMFMS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUCHENNE MUSCULAR-DYSTROPHY; VERTEBRATE NEUROMUSCULAR-JUNCTION; UTROPHIN-DEFICIENT MICE; TORPEDO ELECTRIC ORGAN; GA-BINDING-PROTEIN; N-BOX MOTIF; ACETYLCHOLINE-RECEPTOR; POSTSYNAPTIC PROTEIN; BETA-DYSTROBREVIN; MDX MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, KE Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, S Parks Rd, Oxford OX1 3QX, England Univ Oxford S Parks Rd Oxford England OX1 3QX OX1 3QX, England
Citazione:
S.E. Newey et al., "A novel mechanism for modulating synaptic gene expression: Differential localization of alpha-dystrobrevin transcripts in skeletal muscle", MOL CELL NE, 17(1), 2001, pp. 127-140

Abstract

alpha -Dystrobrevin is a dystrophin-related and -associated protein that is involved in synapse maturation and is required for normal muscle function. There are three protein isoforms in skeletal muscle, alpha -dystrobrevin-1, -2, and -3 that are encoded by the single alpha -dystrobrevin gene. To understand the role of these proteins in muscle we have investigated the localisation and transcript distribution of the different alpha -dystrobrevin isoforms. alpha -Dystrobrevin-1 and -2 are concentrated at the neuromuscular junction and are both recruited into agrin-induced acetylcholine receptorclusters in cultured myotubes. We also demonstrate that all a-dystrobrevinmRNAs are transcribed from a single promoter in skeletal muscle. However, only transcripts encoding alpha -dystrobrevin-1 are preferentially accumulated at postsynaptic sites. These data suggest that the synaptic accumulation of alpha -dystrobrevin-1 mRNA occurs posttranscriptionally, identifying anovel mechanism for synaptic gene expression. Taken together, these results indicate that different isoforms possess distinct roles in synapse formation and possibly in the pathogenesis of muscular dystrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:56:54