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Titolo:
TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion
Autore:
Lee, BJ; Cho, GJ; Norgren, RB; Junier, MP; Hill, DF; Tapia, V; Costa, ME; Ojeda, SR;
Indirizzi:
Oregon Hlth Sci Univ, Reg Primate Res Ctr, Div Neurosci, Beaverton, OR 97006 USA Oregon Hlth Sci Univ Beaverton OR USA 97006 osci, Beaverton, OR 97006 USA Univ Ulsan, Coll Nat Sci, Dept Biol Sci, Ulsan 680749, South Korea Univ Ulsan Ulsan South Korea 680749 Biol Sci, Ulsan 680749, South Korea
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 1, volume: 17, anno: 2001,
pagine: 107 - 126
SICI:
1044-7431(200101)17:1<107:TAHGRF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; GROWTH-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; ENHANCER-BINDING PROTEIN; CA3 HIPPOCAMPAL-NEURONS; LUTEINIZING-HORMONE; TRANSCRIPTION FACTOR; FEMALE RAT; FACTOR-I; PRECOCIOUS PUBERTY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Ojeda, SR Oregon Hlth Sci Univ, Reg Primate Res Ctr, Div Neurosci, 505 NW 185th Ave,Beaverton, OR 97006 USA Oregon Hlth Sci Univ 505 NW 185th Ave Beaverton OR USA 97006 USA
Citazione:
B.J. Lee et al., "TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion", MOL CELL NE, 17(1), 2001, pp. 107-126

Abstract

TTF-1 is a member of the Nkx family of homeodomain genes required for morphogenesis of the hypothalamus. Whether TTF-1, or other Nkx genes, contributes to regulating differentiated hypothalamic functions is not known. We nowreport that postnatal hypothalamic TTF-1 expression is developmentally regulated and associated with the neuroendocrine process of female sexual development. Lesions of the hypothalamus that cause sexual precocity transiently activate neuronal TTF-1 expression near the lesion site. In intact animals, hypothalamic TTF-1 mRNA content also increases transiently, preceding the initiation of puberty. Postnatal expression of the TTF-1 gene was limitedto subsets of hypothalamic neurons, including LHRH neurons, which control sexual maturation, and preproenkephalinergic neurons of the lateroventromedial nucleus of the basal hypothalamus, which restrain sexual maturation andfacilitate reproductive behavior. TTF-1 mRNA was also detected in astrocytes of the median eminence and ependymal/subependymal cells of the third ventricle, where it colocalized with erbB-2, a receptor involved in facilitating sexual development. TTF-1 binds to and transactivates the erbB-2 and LHRH promoters, but represses transcription of the preproenkephalin gene. The singular increase in hypothalamic TTF-1 gene expression that precedes the initiation of puberty, its highly specific pattern of cellular expression, and its transcriptional actions on genes directly involved in neuroendocrinereproductive regulation suggest that TTF-1 may represent one of the controlling factors that set in motion early events underlying the central activation of mammalian puberty.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:58:07