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Titolo:
Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblastgrowth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats
Autore:
Clarke, WE; Berry, M; Smith, C; Kent, A; Logan, A;
Indirizzi:
Univ Birmingham, Dept Med, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England GKT, Ctr Neurosci Neural Damage & Repair, London SE1 1UL, England GKT London England SE1 1UL ural Damage & Repair, London SE1 1UL, England
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 1, volume: 17, anno: 2001,
pagine: 17 - 30
SICI:
1044-7431(200101)17:1<17:COFGFR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT FORMS; FACTOR-LIKE IMMUNOREACTIVITY; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; FACTOR BFGF; ENDOTHELIAL-CELLS; CYTOPLASMIC LOCALIZATION; FOREBRAIN ISCHEMIA; BRAIN INJURY; IN-VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Clarke, WE Univ Birmingham, Dept Med, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT England
Citazione:
W.E. Clarke et al., "Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblastgrowth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats", MOL CELL NE, 17(1), 2001, pp. 17-30

Abstract

Traumatic injury to the adult central nervous system initiates a cascade of cellular and trophic events, culminating in the formation of a reactive gliotic scar through which transected axons fail to regenerate. Levels of fibroblast growth factor-2 (FGF-2), a potent gliogenic and neurotrophic factor, together with its full-length receptor, FGF receptor 1 (FGFR1) are coordinately and significantly increased postinjury in both nuclear and cytoplasmic fractions of extracted cerebral cortex biopsies after a penetrant injury. FGFR1 is colocalized with FGF-2 in the nuclei of reactive astrocytes, and here FGF-2 is associated with nuclear euchromatin. This study unequivocally demonstrates coordinate up-regulation and trafficking of FGF-2 and full-length FGFR1 to the nucleus of reactive astrocytes in an in vivo model of brain injury, thereby implicating a role in nuclear activity for these molecules. However, the precise contribution of nuclear FGF-2/FGFR1 to the pathophysiological response of astrocytes after injury is undetermined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 22:59:50