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Titolo:
Role of nitric oxide in the metabolism of arachidonic acid in the rat anterior pituitary gland
Autore:
Velardez, MO; Ogando, D; Franchi, AM; Duvilanski, BH;
Indirizzi:
Univ Buenos Aires, Fac Med, Ctr Invest Reprod, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina CONICET, Ctr Estudios Farmacol & Bot, RA-1033 Buenos Aires, DF, Argentina CONICET Buenos Aires DF Argentina RA-1033 033 Buenos Aires, DF, Argentina
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 172, anno: 2001,
pagine: 7 - 12
SICI:
0303-7207(20010214)172:1-2<7:RONOIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOXYGENASE PATHWAY; LUTEINIZING-HORMONE; PROLACTIN-RELEASE; SECRETION; SYNTHASE; CELLS; INVOLVEMENT; INVITRO; LOCALIZATION; CALCIUM;
Keywords:
nitric oxide; lipooxygenase; cyclooxygenase; anterior pituitary; prolactin; 5-HETE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Duvilanski, BH Univ Buenos Aires, Fac Med, Ctr Invest Reprod, Paraguay 2155,Piso 10, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155,Piso 10 Buenos Aires DF Argentina RA-1121
Citazione:
M.O. Velardez et al., "Role of nitric oxide in the metabolism of arachidonic acid in the rat anterior pituitary gland", MOL C ENDOC, 172(1-2), 2001, pp. 7-12

Abstract

Nitric oxide (NO) affects cyclooxygenase (COX) and lipooxygenase (LOX) activities in several tissues. The aim of this study was to investigate the effect of NO on the AA metabolism in the anterior pituitary. LOX and COX products from anterior pituitaries of Wistar male rats were determined by [C-14]-AA radioconversion method. Sodium nitroprusside (NP, 0.5 mM) and DETA NONOate (1 mM), NO donors, decreased 5-hydroxy-5,8,11,14-eicosatetraenoic acid(5-HETE) synthesis (P < 0.05), effects that were reversed by hemoglobin. L-arginine also inhibited LOX activity. To the contrary, the inhibition of NO synthase by L-NAME (0.5 mM) or aminoguanidine (0.5 mM) increased 5-HETE production (P < 0.05). COX activity was slightly stimulated by NP and L-arginine. However, DETA NONOate induced a stimulation of the synthesis of all prostanoids (P < 0.05), this effect being reversed by hemoglobin. Neither NOS inhibitors nor hemoglobin modified basal prostanoids synthesis. These results indicate that NO inhibits LOX activity and stimulates COX activity in the anterior pituitary gland. The inhibition of LOX by NO may be another mechanism involved in the effects of NO on hormone release in the anterior pituitary. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:49:46