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Titolo:
In vivo diffusion measurements as an indication of fetal lung maturation using echo planar imaging at 0.5T
Autore:
Moore, RJ; Strachan, B; Tyler, DJ; Baker, PN; Gowland, PA;
Indirizzi:
Univ Nottingham, Magnet Resonance Ctr, Sch Phys & Astron, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England Univ Nottingham, City Hosp, Sch Human Dev, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 247 - 253
SICI:
0740-3194(200102)45:2<247:IVDMAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE; IN-UTERO; HUMAN-FETUS; MOTION; GROWTH; RESTRICTION; GESTATION; PERFUSION; GRADIENT;
Keywords:
fetus; lung; EPI; PGSE; diffusion; maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gowland, PA Univ Nottingham, Magnet Resonance Ctr, Sch Phys & Astron, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD NG7 2RD, England
Citazione:
R.J. Moore et al., "In vivo diffusion measurements as an indication of fetal lung maturation using echo planar imaging at 0.5T", MAGN RES M, 45(2), 2001, pp. 247-253

Abstract

The aim of this study was twofold: First, to establish the normal range offetal lung diffusion values measured during healthy pregnancy; and second,to determine whether fetal lung diffusion could be used as an indication of fetal lung maturity. The apparent diffusion coefficient (ADC), averaged over all 26 subjects with an average gestational age of 29 +/- 6 weeks (mean+/- sd), was found to be 2.0 +/- 0.6 x 10(-9) m(2)/sec (mean +/- sd), but a trend was found indicating that ADC increased with gestational age at therate of 0.07 x 10(-9) m(2)/sec per week (P = 4 x 10(-5)). To determine theusefulness of this data in predicting lung maturity, a simple three-compartment model was proposed which was comprised of intra-lung amniotic fluid, intratissue water, and Vascular blood. The relative proportions of each compartment were taken from the literature, and exchange between the compartments was assumed to be minimal. This model predicted the in vivo data reasonably well, and indicated that MR measurements of fetal lung diffusion are amarker for the degree of vascularization of the terminal tubules. Magn Reson Med 45:247-253, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:23:49