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Titolo:
Regional modulation of BOLD MRI responses to human sensorimotor activationby transcranial direct current stimulation
Autore:
Baudewig, J; Nitsche, MA; Paulus, W; Frahm, J;
Indirizzi:
Biomed NMR Forsch GmbH, D-37070 Gottingen, Germany Biomed NMR Forsch GmbHGottingen Germany D-37070 7070 Gottingen, Germany Max Planck Inst Biophys Chem, D-3400 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-3400 Gottingen, Germany Univ Gottingen, Abt Klin Neurophysiol, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 ysiol, D-3400 Gottingen, Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 2, volume: 45, anno: 2001,
pagine: 196 - 201
SICI:
0740-3194(200102)45:2<196:RMOBMR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD OXYGENATION; MOTOR EVOKED-POTENTIALS; FUNCTIONAL MRI; CYCLIC-AMP; CORTEX; BRAIN; ACETAZOLAMIDE;
Keywords:
magnetic resonance imaging; functional brain activation; functional neuroimaging; direct current stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Frahm, J Biomed NMR Forsch GmbH, D-37070 Gottingen, Germany Biomed NMR Forsch GmbH Gottingen Germany D-37070 ingen, Germany
Citazione:
J. Baudewig et al., "Regional modulation of BOLD MRI responses to human sensorimotor activationby transcranial direct current stimulation", MAGN RES M, 45(2), 2001, pp. 196-201

Abstract

Blood oxygenation level dependent (BOLD) MRI was used to monitor modulations of human sensorimotor activity by prior transcranial direct current stimulation (tDCS), Activation maps for a right hand sequential finger opposition task were obtained for six subjects before as well as 0-5 min and 15-20 min after a 5-min period of 1 mA cathodal and, in a separate session, anodal tDCS of the left-hemispheric motor cortex, Cathodal tDCS resulted in a global decrease of the mean number of activated pixels by 38% (P < 0.01) 0-5 min after stimulation, which reduced to 28% (P < 0.05) 15-20 min after stimulation, A region-of-interest analysis revealed a 57% decrease of activatedpixels (P < 0.001) in the supplementary motor area, but no change in the hand area of the primary motor cortex. Anodal tDCS yielded a nonsignificant 5% increase of activated pixels with no regional differences, These findings support the view that reduced neuroaxonal excitability after cathodal tDCS causes reduced brain activity, However, rather than affecting the primarysensorimotor input of an active task, the process appears to dampen those responses that rely on cortico-cortical connections and related processing. Magn Reson Med 45: 196-201, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:25:11