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Titolo:
Hypermethylation of p16(INK4A) gene promoter during the progression of plasma cell dyscrasia
Autore:
Uchida, T; Kinoshita, T; Ohno, T; Ohashi, H; Nagai, H; Saito, H;
Indirizzi:
Nagoya Daini Red Cross Hosp, Dept Hematol, Showa Ku, Nagoya, Aichi 4668650, Japan Nagoya Daini Red Cross Hosp Nagoya Aichi Japan 4668650 chi 4668650, Japan Nagoya Univ, Sch Med, Dept Internal Med 1, Nagoya, Aichi 466, Japan NagoyaUniv Nagoya Aichi Japan 466 ternal Med 1, Nagoya, Aichi 466, Japan
Titolo Testata:
LEUKEMIA
fascicolo: 1, volume: 15, anno: 2001,
pagine: 157 - 165
SICI:
0887-6924(200101)15:1<157:HOPGPD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-MYELOMA; DNA METHYLATION; MYELODYSPLASTIC SYNDROMES; P15(INK4B) GENE; LUNG-CANCER; P16 GENE; LEUKEMIA; LYMPHOMA; INACTIVATION; MALIGNANCIES;
Keywords:
p16(INK4A); p15(INK4B); promoter hypermethylation; disease progression; plasma cell dyscrasia; tumor suppressor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Uchida, T Nagoya Daini Red Cross Hosp, Dept Hematol, Showa Ku, 2-9 Myoken Cho, Nagoya, Aichi 4668650, Japan Nagoya Daini Red Cross Hosp 2-9 Myoken Cho Nagoya Aichi Japan 4668650
Citazione:
T. Uchida et al., "Hypermethylation of p16(INK4A) gene promoter during the progression of plasma cell dyscrasia", LEUKEMIA, 15(1), 2001, pp. 157-165

Abstract

Recent studies have indicated a close relationship between inactivation oftumor suppressor genes (TSGs) and disease progression. The genes encoding the cyclin-dependent kinase inhibitors p16(INK4A) and p15(INK4B) are potentTSGs, and correlations between their inactivation and disease progression have also been reported in various malignancies. In this study, we analyzedthe methylation status of p16(INK4A) and p15(INK4B) gene promoters in plasma cell dyscrasias (PCDs) by methylation-specific PCR (MSP), In analyses using DNAs extracted from bone marrow mononuclear cells (BM-MNCs), patients with multiple myeloma (MM) showed frequent hypermethylation of the p16(INK4A) gene (15/37, 41%), whereas p15(INK4B) gene methylation was not so frequent (5/37, 14%), Many patients whose BM-MNC showed dense methylation of the p16(INK4A) gene had extramedullary plasmacytoma (extra-PC), and all available extra-PC samples showed alterations of the p16(INK4A) gene (4; dense methylation, 1; homozygous deletion). In contrast to MM, hypermethylation of the p16(INK4A) gene was significantly infrequent in indolent PCDs (2/22, 9%, P = 0.0055), The infrequency in indolent PCDs was also confirmed by analyses using DNAs extracted from BM smears (1/29, 3%). It is possible that hypermethylation of the p16(INK4A) gene promoter contributes to progression to aggressive MM from indolent PCD, especially to extra-PC development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:29:56