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Titolo:
Dental implants using recombinant human osteogenic protein-1.
Autore:
Terheyden, H; Jepsen, S; Moller, B; Rueger, D;
Indirizzi:
Univ Kiel, Klin Mund Kiefer & Gesichtschirurg, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 & Gesichtschirurg, D-24105 Kiel, Germany
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 1, volume: 80, anno: 2001,
pagine: 47 - 51
SICI:
1615-0007(200101)80:1<47:DIURHO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
GER
Soggetto:
DIFFERENT GRAFTING MATERIALS; BONE MORPHOGENETIC PROTEINS; MAXILLARY SINUS; MANDIBULAR RECONSTRUCTION; POROUS HYDROXYAPATITE; TITANIUM IMPLANTS; MINIATURE PIGS; MONKEYS; REGENERATION;
Keywords:
dental implants; sinus lift operation; bone morphogenetic proteins; osteogenic protein-1; osteoinductive proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Terheyden, H Univ Kiel, Klin Mund Kiefer & Gesichtschirurg, Arnold Heller Str 16, D-24105 Kiel, Germany Univ Kiel Arnold Heller Str 16 Kiel Germany D-24105 Germany
Citazione:
H. Terheyden et al., "Dental implants using recombinant human osteogenic protein-1.", LARY RH OTO, 80(1), 2001, pp. 47-51

Abstract

The purpose of this study was to examine whether the combination of an osteoinductive protein (recombinant human osteogenic protein- (rhOP-1 = bone morphogenetic protein-7) with natural bovine bone mineral (BioOss(R)) would improve ossification and the bone-implant contact (BIC) in a sinus floor augmentation with simultaneous placement of implants. Material and Methods: In this study, the maxillary sinus floors in five miniature pigs were augmented with 3 ml BioOs(R) containing 420 mug rhOP-1 on the test side and 3 ml BioOss(R) alone on the control side. At the time of caudal direction. Results: After 6 months of heating the sites of augmentation were removed and examined in non-decalcified sections by microradiography, fluorescence microscopy of sequentially labelled specimens and by histometry. On both sides, significant amounts of newly formed bone were observed. However, on the testsites, the BIC in the augmented area was 80.0% versus 38.6% on control sites. It can be concluded that the application of bone morphogenetic proteinscaused a more rapid and enhanced osseointegration of simultaneously placedimplants when compared to the bone substitute alone. Discussion: Thereforerecombinant human osteogenic protein-1 delivered by natural bone mineral has the potential to become a clinical alternative for autogenous bone grafts in sinus floor augmentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:47:04