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Titolo:
Anemia is associated with hypercholesterolemia in rats only when liver iron is elevated
Autore:
Fields, M; Lewis, CG;
Indirizzi:
ARS, USDA, BHNRC, NRFL, Beltsville, MD 20705 USA ARS Beltsville MD USA 20705 , USDA, BHNRC, NRFL, Beltsville, MD 20705 USA
Titolo Testata:
JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 81 - 87
SICI:
0896-548X(2001)14:1<81:AIAWHI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
COPPER-DEFICIENT RATS; ISCHEMIC-HEART-DISEASE; DIETARY IRON; LIPID-METABOLISM; HYPERLIPIDEMIA; ACCUMULATION; PATHOLOGY; OVERLOAD; FRUCTOSE;
Keywords:
iron deficiency anemia; topper deficiency anemia; hypercholesterolemia; hypertriglyceridemia; liver iron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fields, M ARS, USDA, BHNRC, NRFL, Bldg 307,Rm 330,BARC-E, Beltsville, MD 20705 USA ARS Bldg 307,Rm 330,BARC-E Beltsville MD USA 20705 MD 20705 USA
Citazione:
M. Fields e C.G. Lewis, "Anemia is associated with hypercholesterolemia in rats only when liver iron is elevated", J TR EL EXP, 14(1), 2001, pp. 81-87

Abstract

The objective of this study was designed to answer the question whether anemia per sc is a potential inducer of hyperlipidemia. For this purpose, twotypes of anemia were induced; copper-deficiency and iron-deficiency anemia. Seventy-two weanling male Sprague-Dawley rats were assigned randomly to 12 dietary groups differing in the levels of copper, iron, and the types of dietary carbohydrates. The rats were fed either a copper-deficient (0.6 mugCu/g) or adequate (6.0 mug Cu/g) diets containing either low (5), adequate(50), or high (500) mug Fe/g The diets also contained fructose or starch as the sole source of dietary carbohydrate. All iron-deficient rats became anemic. Copper-deficient rats developed anemia only when they consumed the diet containing fructose and when they consumed the high levels of dietary iron. Anemia, per se, was not associated with elevated levels of blood cholesterol or triglycerides unless the diet consumed was deficient in copper and was either high in iron or contained fructose. The most severe hypercholesterolemia developed in rats fed the copper-deficient diet, which containedhigh levels of iron. These rats also exhibited high levels of liver iron. The highest degree of hypertriglyceridemia developed in copper deficient rats fed the fructose-based diet. Data show that anemia per se was not associated with hypercholesterolemia. Similarly, excess liver iron by itself was not accompanied with hypercholesterolemia. The combination of anemia with excess liver iron was instrumental in raising blood cholesterol. J. Trace Elem. Exp. Med. 14:81-87, 2001. Published 2001 Wiley-Liss, Inc.

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Documento generato il 22/01/20 alle ore 18:28:35