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Titolo:
Relationships between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard
Autore:
Skaare, JU; Bernhoft, A; Wiig, O; Norum, KR; Haug, E; Eide, DM; Derocher, AE;
Indirizzi:
Natl Vet Inst, N-0033 Oslo, Norway Natl Vet Inst Oslo Norway N-0033Natl Vet Inst, N-0033 Oslo, Norway Norwegian Sch Vet Sci, Oslo, Norway Norwegian Sch Vet Sci Oslo NorwayNorwegian Sch Vet Sci, Oslo, Norway Univ Oslo, Zool Museum, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Zool Museum, Oslo, Norway Univ Oslo, Oslo, Norway Univ Oslo Oslo NorwayUniv Oslo, Oslo, Norway Aker Univ Hosp, Oslo, Norway Aker Univ Hosp Oslo NorwayAker Univ Hosp, Oslo, Norway Norwegian Polar Res Inst, Tromso, Norway Norwegian Polar Res Inst TromsoNorway n Polar Res Inst, Tromso, Norway
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 4, volume: 62, anno: 2001,
pagine: 227 - 241
SICI:
1528-7394(200102)62:4<227:RBPLOO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORINATED-HYDROCARBON CONTAMINANTS; POLYCHLORINATED-BIPHENYLS PCBS; THYROXINE-BINDING GLOBULIN; DIBENZO-PARA-DIOXINS; MINK MUSTELA-VISON; VITAMIN-A LEVELS; FRACTIONS THEREOF; MARINE MAMMALS; RAT-LIVER; TRANSTHYRETIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Skaare, JU Natl Vet Inst, POB 8156 DEP, N-0033 Oslo, Norway Natl Vet Inst POB 8156 DEP Oslo Norway N-0033 033 Oslo, Norway
Citazione:
J.U. Skaare et al., "Relationships between plasma levels of organochlorines, retinol and thyroid hormones from polar bears (Ursus maritimus) at Svalbard", J TOX E H A, 62(4), 2001, pp. 227-241

Abstract

Associations were determined between retinol and the thyroid hormones thyroxine (T4) and triiodothyronine (T3), respectively, and the organochlorine contaminants (OCs) polychlorinated biphenyls (PCBs), 1,1-dichloro-2,2-bis-(4-chlorophenyl)ethylene (DDE), hexachlorobenzene (HCB), and hexachlorocyclohexanes (HCHs) in blood plasma from polar bears (Ursus maritimus) caught atSvalbard. The blood samples were collected from free-ranging polar bears of different age and sex in 1991-1994. The retinol concentration and the ratio of total T4 (TT4) to free T4(FT4) (TT4/FT4 ratio) decreased linearly with increasing concentrations of PCBs and HCB. Retinol was also negatively associated with HCHs, while the TT4/FT4 ratio was positively associated with DDE. The concentrations of retinol and thyroid hormones were significantly higher in females than in males. However, the TT4/FT4 and TT3/FT3 ratios were significantly higher in males than in females. The concentrations of thyroid hormones were negatively correlated with age in male bears, while in females, thyroid hormones did not change with age. The OCs were found to explain 12, 30, and 7% of the variation of retinol concentrations and the TT4/FT4 and TT3/FT3 ratios, respectively, after correcting for age and sex. Thepotential consequence of these associations for the individual and the population is unknown.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:20:25