Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bovine casein peptides co-stimulate naive macrophages with lipopolysaccharide for proinflammatory cytokine production and nitric oxide release
Autore:
Xiao, CW; Jin, LZ; Zhao, X;
Indirizzi:
McGill Univ, Dept Anim Sci, St Anne De Bellevue, PQ H9X 3V9, Canada McGillUniv St Anne De Bellevue PQ Canada H9X 3V9 vue, PQ H9X 3V9, Canada
Titolo Testata:
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
fascicolo: 3, volume: 81, anno: 2001,
pagine: 300 - 304
SICI:
0022-5142(200102)81:3<300:BCPCNM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MILK-PROTEINS; FACTOR-ALPHA; ENTAMOEBA-HISTOLYTICA; TRIPEPTIDES; MURINE; BLOOD; CELLS; GENE;
Keywords:
bovine casein peptide; cytokine; nitric oxide; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, X McGill Univ, Dept Anim Sci, Macdonald Campus,21111 Lakeshore Rd, St Anne De Bellevue, PQ H9X 3V9, Canada McGill Univ Macdonald Campus,21111 Lakeshore Rd St Anne De Bellevue PQ Canada H9X 3V9
Citazione:
C.W. Xiao et al., "Bovine casein peptides co-stimulate naive macrophages with lipopolysaccharide for proinflammatory cytokine production and nitric oxide release", J SCI FOOD, 81(3), 2001, pp. 300-304

Abstract

Three bovine casein peptides, ie LLY, PGPIPN and TTMPLW, were used to investigate their effects on cytokine (TNF-alpha and IL-6) production and nitric oxide (NO) release by murine bone marrow macrophages (BMMs). The results showed that these peptides alone were incapable of stimulating cytokine production or NO release in naive or IFN-gamma -primed BMMs. However, when BMMs were coincubated with the peptides at a concentration of 1.0 muM and Lipopolysaccharide (LPS; 100ng ml(-1)), an augmentative effect on TNF-alpha, IL-6, and NO production was observed. Of the three peptides, TTMPLW had the greatest augmentative effect on NO production by LPS-stimulated BMMs and induced the highest amount of TNF-alpha production at a concentration of 1.0 muM. All the peptides at a concentration of 1.0 muM stimulated IL-6 production by BMMs. TNF-alpha was neutralised by anti-TNF-alpha monoclonal antibodyand the release of NO was reduced by about 33.3% (p <0.01). These results demonstrate that bovine casein peptides can co-stimulate naive macrophages with LPS for proinflammatory cytokine production and NO release and may play a role in host defence against pathogens. (C) 2000 Society of Chemical Industry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:28:55