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Titolo:
Fluvoxamine for children and adolescents with obsessive-compulsive disorder: A randomized, controlled, multicenter trial
Autore:
Riddle, MA; Reeve, EA; Yaryura-Tobias, JA; Yang, HM; Claghorn, JL; Gaffney, G; Greist, JH; Holland, D; McConville, BJ; Pigott, T; Walkup, JT;
Indirizzi:
Johns Hopkins Med Inst, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 st, Baltimore, MD 21205 USA St Paul Ramsey Med Ctr, St Paul, MN 55101 USA St Paul Ramsey Med Ctr St Paul MN USA 55101 ed Ctr, St Paul, MN 55101 USA Inst Biobehav Therapy & Res, Great Neck, NY USA Inst Biobehav Therapy & Res Great Neck NY USA & Res, Great Neck, NY USA Solvay Pharmaceut, Marietta, GA USA Solvay Pharmaceut Marietta GA USASolvay Pharmaceut, Marietta, GA USA Clin Res Associates, Houston, TX USA Clin Res Associates Houston TX USAClin Res Associates, Houston, TX USA Univ Iowa, Med Ctr, Iowa City, IA USA Univ Iowa Iowa City IA USAUniv Iowa, Med Ctr, Iowa City, IA USA Healthcare Technol Syst, Madison, WI USA Healthcare Technol Syst Madison WI USA are Technol Syst, Madison, WI USA Boca Raton Psychiat Grp, Boca Raton, FL USA Boca Raton Psychiat Grp Boca Raton FL USA ychiat Grp, Boca Raton, FL USA Univ Cincinnati, Coll Med, Cincinnati, OH 45221 USA Univ Cincinnati Cincinnati OH USA 45221 oll Med, Cincinnati, OH 45221 USA Univ Texas, Med Branch, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 as, Med Branch, Galveston, TX 77550 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 2, volume: 40, anno: 2001,
pagine: 222 - 229
SICI:
0890-8567(200102)40:2<222:FFCAAW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; CLOMIPRAMINE TREATMENT; PLACEBO; PHENOMENOLOGY; DESIPRAMINE; RELIABILITY; DEPRESSION; SERTRALINE; FLUOXETINE; VALIDITY;
Keywords:
fluvoxamine; obsessive-compulsive disorder; psychopharmacology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Riddle, MA Johns Hopkins Hosp, Div Child & Adolescent Psychiat, CMSC 346,600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Hosp CMSC 346,600 N Wolfe St Baltimore MD USA 21287
Citazione:
M.A. Riddle et al., "Fluvoxamine for children and adolescents with obsessive-compulsive disorder: A randomized, controlled, multicenter trial", J AM A CHIL, 40(2), 2001, pp. 222-229

Abstract

Objective: To determine the safety and efficacy of fluvoxamine for the treatment of children and adolescents with obsessive-compulsive disorder (OCD)with a double-blind, placebo-controlled, multicenter study. Method: Subjects, aged 8 to 17 years, meeting DSM-III-R criteria for OCD were recruited from July 1991 to August 1994. After a 7- to 14-day single-blind, placebo washout/screening period, subjects were randomly assigned to fluvoxamine 50 to 200 mg/day or placebo for 10 weeks. Subjects who had not responded after 6 weeks could discontinue the double-blind phase of the study and enter a long-term, open-label trial of fluvoxamine. Analyses used an intent-to-treatsample with a last-observation-carried-forward method. Results: Mean Chirdren's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) scores with fluvoxamine were significantly (p<.05) different from those with placebo at weeks 1,2, 3, 4, 6, and 10. Significant (p <.05) differences between fluvoxamine and placebo were observed for all secondary outcome measures at all visits. Based on a 25% reduction of CY-BOCS scores, 42% of subjects taking fluvoxamine were responders compared with 26% taking placebo. Forty-six (19 fluvoxamine, 27 placebo) of 120 randomized subjects discontinued early Adverse events with a placebo-adjusted rate greater than 10% were insomnia and asthenia. Conclusions: Fluvoxamine has a rapid onset of action and is well tolerated acid efficacious for the short-term treat ment of pediatric OCD.

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Documento generato il 23/01/20 alle ore 04:22:43