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Titolo:
Quetiapine and obsessive-compulsive symptoms (OCS): case report and reviewof atypical antipsychotic-induced OCS
Autore:
Khullar, A; Chue, P; Tibbo, P;
Indirizzi:
Univ Alberta, Edmonton, AB, Canada Univ Alberta Edmonton AB CanadaUniv Alberta, Edmonton, AB, Canada Univ Alberta Hosp, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada Alberta Hosp, Edmonton, AB, Canada Alberta Hosp Edmonton AB CanadaAlberta Hosp, Edmonton, AB, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 1, volume: 26, anno: 2001,
pagine: 55 - 59
SICI:
1180-4882(200101)26:1<55:QAOS(C>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND; DISORDER; CLOZAPINE; SCHIZOPHRENIA; OLANZAPINE; RISPERIDONE; PLACEBO; SEROTONIN; EMERGENCE; DOPAMINE;
Keywords:
antipsychotic agents; clozapine; dopamine; haloperidol; obsessive-compulsive disorder; receptors, serotonin; risperidone; schizophrenia; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chue, P Psychopharmacol Res Unit, 10-126 Clin Sci Bldg,8440-112 St, Edmonton, AB T6G 2B7, Canada Psychopharmacol Res Unit 10-126 Clin Sci Bldg,8440-112 St Edmonton AB Canada T6G 2B7
Citazione:
A. Khullar et al., "Quetiapine and obsessive-compulsive symptoms (OCS): case report and reviewof atypical antipsychotic-induced OCS", J PSYCH NEU, 26(1), 2001, pp. 55-59

Abstract

The atypical antipsychotics have advanced the treatment of schizophrenia and have proved to be effective agents in treating other disorders with or without psychotic features. We review the literature concerning an increasingly reported and interesting adverse effect, atypical antipsychotic-inducedobsessive-compulsive symptoms (OCS). The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented. Mechanisms, including 5-HT2A and 5-HT2C antagonism, serotonergic regulation of dopamine systems and putative dopaminergic subtypes of OCS and OCD, are discussed. Given the paradoxical efficacy of the atypical antipsychotics in pure OCD, the neurobiology and comorbidity of OCD and schizophrenia, as well as the increasing use of atypical antipsychotics, a cautious and rational pharmacotherapeutic treatment approach is recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:13:02