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Titolo:
Vascular endothelial growth factor-mediated endothelium-dependent relaxation is blunted in spontaneously hypertensive rats
Autore:
Liu, MH; Jin, HK; Floten, HS; Yang, Q; Yim, APC; Furnary, A; Zioncheck, TF; Bunting, S; He, GW;
Indirizzi:
St Vincent Hosp, Providence Heart Inst, Starr Acad Ctr Cardiac Surg, Portland, OR USA St Vincent Hosp Portland OR USA Acad Ctr Cardiac Surg, Portland, OR USA Genentech Inc, Cardiovasc Res, San Francisco, CA 94080 USA Genentech Inc San Francisco CA USA 94080 Res, San Francisco, CA 94080 USA Chinese Univ Hong Kong, Dept Surg, Cardiovasc Surg Res Lab, Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Hong Kong PeoplesR China oples R China
Titolo Testata:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
fascicolo: 2, volume: 296, anno: 2001,
pagine: 473 - 477
SICI:
0022-3565(200102)296:2<473:VEGFER>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPEUTIC ANGIOGENESIS; PERMEABILITY FACTOR; BLOOD-FLOW; HYPERPOLARIZATION; REVASCULARIZATION; ACETYLCHOLINE; ACCUMULATION; ARTERY; CELLS; BOLUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: He, GW Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Div Cardiothorac Surg, Block B,5A, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Block B,5A Shatin Hong Kong Peoples R China
Citazione:
M.H. Liu et al., "Vascular endothelial growth factor-mediated endothelium-dependent relaxation is blunted in spontaneously hypertensive rats", J PHARM EXP, 296(2), 2001, pp. 473-477

Abstract

The vasodilatory effect of VEGF has not been characterized in the setting of hypertension. This study investigated the in vitro vasorelaxant effects of VEGF in organ chambers in the aorta of the adult (12-week-old) spontaneously hypertensive rats (SHR), young (4-week-old) SHR without hypertension, and age-matched Wistar-Kyoto (WKY) rats compared with acetylcholine (ACh). Cumulative concentration-relaxation curves were established for VEGF (similar to 10(-12)-10(-8.5) M) and ACh (similar to 10(-10)-10(-5) M) in U46619 (10(-8) M)- induced contraction. VEGF induced endothelium-dependent relaxation that was significantly reduced in the adult SHR compared with the age-matched WKY control (87.8 +/- 2.8 versus 61.4 +/- 8.6%, P = 0.01). These responses were significantly attenuated by pretreatment with N-omega-nitro-L-arginine (L-NNA, 300 muM) alone (SHR: 25.1 +/- 1.9%; WKY: 21.0 +/- 2.6%; P = 0.01) or indomethacin (7 muM) + L-NNA (SHR: 30.2 +/- 2.1%; WKY: 35.0 +/- 2.9%; P = 0.01). Further addition of oxyhemoglobin (20 muM) abolished the residual relaxation and reduced the relaxation induced by nitroglycerin. ACh induced similar responses to VEGF. In contrast, pretreatment with indomethacin alone enhanced VEGF- or ACh-induced relaxations and the effect was greater in the adult SHR than in WKY rats. In contrast to the adult SHR versus WKY rats, there were no significant differences of VEGF- or ACh-induced relaxations between young SHR and WKY rats. The results demonstrate that VEGF induces endothelium- or nitric oxide-dependent relaxation, which is blunted in the adult SHR. The mechanism of this impairment may be related to decreased release of NO although increased release of contracting factors from the dysfunctional endothelium may also be involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:57:13