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Titolo:
Increase of RM3/1-positive macrophages in radiation-induced oral mucositis
Autore:
Handschel, J; Sunderkotter, C; Prott, FJ; Meyer, U; Kruse-Losler, B; Joos, U;
Indirizzi:
Univ Munster, Clin Cranio & Maxillofacial Surg, Dept Cranio & Maxillofacial Surg, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 cial Surg, D-48149 Munster, Germany Univ Munster, Dept Dermatol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 Dermatol, D-48149 Munster, Germany Univ Munster, Dept Radiotherapy, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 iotherapy, D-48149 Munster, Germany
Titolo Testata:
JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 193, anno: 2001,
pagine: 242 - 247
SICI:
0022-3417(200102)193:2<242:IORMIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE-PROTEIN RM3/1; HUMAN-MONOCYTES; MONOCLONAL-ANTIBODY; PERIPHERAL-BLOOD; IN-VITRO; DIFFERENTIATION ANTIGEN; CELLS; SUBPOPULATIONS; APPEARANCE; SUBSET;
Keywords:
RM3/1; 27E10; 25F9; macrophages; radiotherapy; mouth; mucositis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Handschel, J Univ Munster, Clin Cranio & Maxillofacial Surg, Dept Cranio &Maxillofacial Surg, Waldeyerstr 30, D-48149 Munster, Germany Univ Munster Waldeyerstr 30 Munster Germany D-48149 Germany
Citazione:
J. Handschel et al., "Increase of RM3/1-positive macrophages in radiation-induced oral mucositis", J PATHOLOGY, 193(2), 2001, pp. 242-247

Abstract

The purpose of this study was to describe the distribution patterns of various leukocyte subpopulations in the oral mucosa during the course of radiotherapy and to determine whether there are dose-dependent alterations, or any correlation between the clinical stages and the population density of specific leukocytes, The distribution and density of various leukocytes in oral mucosa in 13 head and neck cancer patients were immunohistochemically analysed before radiotherapy at 30 and 60 Gy and compared with the clinical degree of oral mucositis, Antibodies were used which characterized differentsubtypes of macrophages (27E10, 25F9, RM3/1) and recognized epitopes of granulocytes (CD15) and T cells (CD3, CD4, CD8), The study showed that whereas macrophages reactive with RM3/1 increased significantly at 30 Gy (p < 0.01) and showed a further increase at 60 Gy (p < 0.01), no significant alterations could be detected in the density of macrophages which stained positively for 27E10 or 25F9. Moreover, the percentage of macrophages reactive with RM3/1 showed a non-linear correlation with the clinical mucositis score (p < 0.05), No significant alterations were detected in the percentage of T cells and granulocytes, compared with the values before radiotherapy. In conclusion, radiation-induced mucositis is characterized by features of an intermediate stage of an inflammatory response, suggesting active involvementof down-regulatory macrophages in its pathogenesis, Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:55:32