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Titolo:
Nitric oxide and angiogenesis
Autore:
Ziche, M; Morbidelli, L;
Indirizzi:
Univ Siena, Inst Pharmacol Sci, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Inst Pharmacol Sci, I-53100 Siena, Italy
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 1-2, volume: 50, anno: 2000,
pagine: 139 - 148
SICI:
0167-594X(200010)50:1-2<139:NOAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; HUMAN BRAIN-TUMORS; SYNTHASE MESSENGER-RNA; ARGININE METHYL-ESTER; IN-VIVO; VASCULAR-PERMEABILITY; CARCINOMA-CELLS; MICE LACKING; SUBSTANCE-P; BLOOD-FLOW;
Keywords:
angiogenesis; nitric oxide; nitric oxide synthase; cyclic GMP; vascular endothelial growth factor; tumor angiogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Ziche, M Univ Siena, Inst Pharmacol Sci, Via Piccolomini 170, I-53100 Siena, Italy Univ Siena Via Piccolomini 170 Siena Italy I-53100 Siena, Italy
Citazione:
M. Ziche e L. Morbidelli, "Nitric oxide and angiogenesis", J NEURO-ONC, 50(1-2), 2000, pp. 139-148

Abstract

The steps required for new vessel growth are biologically complex and require coordinate regulation of contributing components, including modifications of cell-cell interactions, proliferation and migration of endothelial cells and matrix degradation. The observation that in vivo angiogenesis is accompanied by vasodilation, that many angiogenesis effectors possess vasodilating properties and that tumor vasculature is in a persistent state of vasodilation, support the existence of a molecular/biochemical link between vasodilation and angiogenesis. Several pieces of evidence converge in the indication of a role for nitric oxide (NO), the factor responsible for vasodilation, in physiological and pathological angiogenesis. Data originated in different labs indicate that NO can act both as an 'actor' of angiogenesis and as a 'director of angiogenesis', both functions being equally expressed during physiological and pathological processes. NO significantly contributes to the prosurvival/proangiogenic program of capillary endothelium by triggering and transducing cell growth and differentiation via endothelial-constitutive NO synthase (ec-NOS) activation, cyclic GMP (cGMP) elevation, mitogen activated kinase (MAPK) activation and fibroblast growth factor-2 (FGF-2) expression. Re-establishment of a balanced NO production in the centralnervous system results in a reduction of cell damage during inflammatory and vascular diseases. Elevation of NOS activity in correlation with angiogenesis and tumor progression has been extensively reported in experimental and human tumors. In the brain, tumor expansion and edema formation are sensitive to NOS inhibition. On this basis, the nitric oxide pathway appears tobe a promising target for consideration in pro- and anti-angiogenic therapeutic strategies. The use of NOS inhibitors seems appropriate to reduce edema, block angiogenesis and facilitate antitumor drug delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:30:04