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Titolo:
Dextran-magnetite complex: conformation of dextran chains and stability ofsolution
Autore:
Kawaguchi, T; Hanaichi, T; Hasegawa, M; Maruno, S;
Indirizzi:
Nagoya Inst Technol, Instrument & Anal Ctr, Showa Ku, Nagoya, Aichi 4668555, Japan Nagoya Inst Technol Nagoya Aichi Japan 4668555 goya, Aichi 4668555, Japan Nagoya Inst Technol, Dept Elect & Comp Engn, Showa Ku, Nagoya, Aichi 4668555, Japan Nagoya Inst Technol Nagoya Aichi Japan 4668555 goya, Aichi 4668555, Japan
Titolo Testata:
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
fascicolo: 2, volume: 12, anno: 2001,
pagine: 121 - 127
SICI:
0957-4530(200102)12:2<121:DCCODC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERPARAMAGNETIC IRON-OXIDE; CONTRAST AGENT; LIVER; PARTICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kawaguchi, T Nagoya Inst Technol, Instrument & Anal Ctr, Showa Ku, Nagoya,Aichi 4668555, Japan Nagoya Inst Technol Nagoya Aichi Japan 4668555 668555, Japan
Citazione:
T. Kawaguchi et al., "Dextran-magnetite complex: conformation of dextran chains and stability ofsolution", J MAT S-M M, 12(2), 2001, pp. 121-127

Abstract

Three kinds of dextran-magnetite (DM) complexes were prepared using alkali-treated dextrans with molecular weights of 1900, 4200 and 9600, respectively. The number of dextrans binding to a magnetite core was determined. The number was proportional to the area of core surface and the area occupied by a dextran was 2.5 nm(2) for molecular weight of 1900, 2.8 for 4200 and 3.8 for 9600. The binding of dextrans to core may be conditioned by the conformation of dextran chains in water (possibly by the steric hindrance between dextrans covering core). Stability of the DM solution was examined at 80 degreesC. Aggregation and/or precipitation of DM particles were observed within two weeks. The stability of DM solution was found to increase with increasing molecular weight of dextran. The dissociation of dextran from the core may cause the aggregation and subsequent precipitation of DM particles (the dissociation constant at 20 degreesC, 3.7 x 10(-6) for a molecular weight of 1900 and 5.4 x 10(-7) for 9600). (C) 2001 Kluwer Academic Publishers.

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Documento generato il 08/04/20 alle ore 11:58:37