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Titolo:
Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes
Autore:
Bregenholt, S; Berche, P; Brombacher, F; Di Santo, JP;
Indirizzi:
Inst Pasteur, Unite Cytokines & Dev Lymphoide, Paris 15, France Inst Pasteur Paris France 15 Cytokines & Dev Lymphoide, Paris 15, France Fac Med Necker Enfants Malad, INSERM, U411, Microbiol Lab, Paris, France Fac Med Necker Enfants Malad Paris France Microbiol Lab, Paris, France Univ Cape Town, ZA-7925 Cape Town, South Africa Univ Cape Town Cape TownSouth Africa ZA-7925 25 Cape Town, South Africa
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 166, anno: 2001,
pagine: 1871 - 1876
SICI:
0022-1767(20010201)166:3<1871:CABTCA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-DEFICIENT MICE; IFN-GAMMA; NATURAL-KILLER; TNF-ALPHA; INFECTION; RESPONSES; IL-12; RESISTANCE; PROTEIN; CHAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Di Santo, JP Inst Pasteur, Unite Cytokines & Dev Lymphoide, 25 Rue DocteurRoux, Paris 15, France Inst Pasteur 25 Rue Docteur Roux Paris France 15 15, France
Citazione:
S. Bregenholt et al., "Conventional alpha beta T cells are sufficient for innate and adaptive immunity against enteric Listeria monocytogenes", J IMMUNOL, 166(3), 2001, pp. 1871-1876

Abstract

We have begun to dissect the cellular requirements for generation of immunity against enteric infection by Listeria monocytogenes using a novel T-B-NK- mouse strain (mice double deficient for the common cytokine receptor gamma -chain (gamma (c)) and the recombinase-activating gene-2 (RAG2/gamma (c)mice). Initial experiments showed that C57BL/6 mice and alymphoid RAG2/gamma (c), mice had similar kinetics of bacterial accumulation in the spleen, liver, and brain early after intragastric L. monocytogenes infection (up today 3), calling into question the physiologic role of gut-associated lymphoid cells during the passage of this enterobacterium into the host. However, in contrast to C57BL/6 mice, RAG2/y(c), mice rapidly succumbed to disseminated infection by day 7. Polyclonal lymph node CD4(+) and CD8(+) alpha beta T cells were able to confer RAG2/gamma (c) mice with long-lasting protection against enteric L. monocytogenes infection in the absence of gamma delta T, NK, and NK-T cells. Moreover, these alpha beta T-reconstituted RAG2/gamma (c) mice produced IFN-gamma at levels comparable to C57BL/6 mice in response to L. monocytogenes both in vitro and in vivo. Protection was IFN-gamma dependent, as RAG2/gamma (c) mice reconstituted with IFN-gamma -deficient alpha beta T cells were unable to control enteric L. monocytogenes infection. Furthermore, alpha beta T cell-reconstituted RAG2/gamma (c) mice were able to mount memory responses when challenged with lethal doses of L. monocytogenes. These data suggest that NK, NK-T, gamma delta T, and B cells arefunctionally redundant in the immunity against oral L. monocytogenes infection, and that in their absence alpha beta T cells are able to mediate the early IFN-gamma production required for both innate and adaptive immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 20:39:55