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Titolo:
p59(fyn) (Fyn) promotes the survival of anergic CD4(-)CD8(-) alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation
Autore:
Utting, O; Priatel, JJ; Teh, SJ; Teh, HS;
Indirizzi:
Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 166, anno: 2001,
pagine: 1540 - 1546
SICI:
0022-1767(20010201)166:3<1540:P(PTSO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASES; CD8 T-CELLS; TRANSGENIC MICE; INTERLEUKIN-2 RECEPTOR; LYMPHOCYTES-T; PHOSPHATIDYLINOSITOL 3-KINASE; CLONAL DELETION; FAMILY PROTEIN; IL-2 RECEPTOR; ENTEROTOXIN-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Teh, HS Univ British Columbia, Dept Microbiol & Immunol, Room 300,6174 Univ Blvd, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Room 300,6174 Univ Blvd Vancouver BC Canada V6T 1Z3
Citazione:
O. Utting et al., "p59(fyn) (Fyn) promotes the survival of anergic CD4(-)CD8(-) alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation", J IMMUNOL, 166(3), 2001, pp. 1540-1546

Abstract

T cell anergy is characterized by alterations in TCR signaling that may play a role in controlling the unresponsiveness of the anergic cell. We have addressed questions regarding the importance of the Src kinase p59(fyn) (Fyn) in this process by using Fyn null mice. We demonstrate that a mature population of CD4(-)CD8(-) alpha beta TCR+ anergic T cells lacking Fyn have a substantial recovery of their proliferation defect in response to Ag stimulation. This recovery cannot be explained by ameliorated production of IL-2,and the improved proliferation correlates with an enhanced ability of the Fyn(-/-) anergic T cells to up-regulate the high affinity IL-2 receptor. Wealso observe that anergic CD4(-)CD8(-) alpha beta TCR+ T cells have a heightened survival ability that is partially dependent on the elevated levels of Fyn and IL-2 receptor beta -chain expressed by these cells. The enhancedsurvival correlates with an increased capacity of the anergic cells to respond to IL-15. We conclude that Fyn plays an important role in aspects of Tcell anergy pertaining to TCR signaling and to cell survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 23:43:10