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Titolo:
Decline of hepatitis C virus load in serum during the first 24 h after administration of in interferon-beta as a predictor of the efficacy of therapy
Autore:
Fukutomi, T; Nakamuta, M; Fukutomi, M; Iwao, M; Watanabe, H; Hiroshige, K; Tanabe, Y; Nawata, H;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Higashi Ku, Fukuoka, Japan Kyushu Univ Fukuoka Japan Bioregulatory Sci, Higashi Ku, Fukuoka, Japan Fukuoka City Hosp, Dept Med, Fukuoka, Japan Fukuoka City Hosp Fukuoka Japan oka City Hosp, Dept Med, Fukuoka, Japan
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 1, volume: 34, anno: 2001,
pagine: 100 - 107
SICI:
0168-8278(200101)34:1<100:DOHCVL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; RECEPTOR MESSENGER-RNA; ALPHA-INTERFERON; VIRAL DYNAMICS; IN-VIVO; EXPRESSION; LIVER; INFECTION; ALFA; PROTEIN;
Keywords:
hepatitis C virus; interferon-beta; viral kinetics; sustained response; HCV-genotype; hyper variable region;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamuta, M Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan shi, Fukuoka, Japan
Citazione:
T. Fukutomi et al., "Decline of hepatitis C virus load in serum during the first 24 h after administration of in interferon-beta as a predictor of the efficacy of therapy", J HEPATOL, 34(1), 2001, pp. 100-107

Abstract

Background/Aims: Hepatitis C virus (HCV) kinetics during interferon (IFN)-alpha treatment have been evaluated recently, however, little is known about the resultant viral kinetics in IFN-beta treatment. In this study, we evaluated HCV kinetics during the first 24 h of IFN-beta treatment, and also assessed their relationship to therapeutic outcomes. Methods: We measured HCV RNA levels at 0 and 24 h after the initiation of IFN-beta treatment, and we calculated the decay slope, viral half-life, andviral production and clearance. Then we analyzed these factors as they related to therapeutic responses with IFN-beta as well as to clinical variables, i.e. genotype, diversity of hyper variable region, and histological findings. Results: Patients with sustained responses (SR) displayed steeper decay slopes of the viral load than those without SR (2.87 +/- 1.41 vs. 1.82 +/- 1.66, P = 0.031). On the other hand, the decay slope was not affected by the clinical variables, The values of viral half-life and viral production and clearance showed no significant correlation to the response and the clinical variables.onclusion: This study demonstrated that the decay slope of the viral load during the first 24 h is related to the virological response to IFN-beta treatment. (C) 2001 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:21:45